Crossover, Multiple Dose Pharmacokinetics of Two Curcumin Formulations in Healthy Volunteers

Inclusion Criteria:

1. 18 - 65 years of age

2. BMI 18 - 30 kg/m^2

3. Ability/willing to provide informed consent

4. Good general health

Exclusion Criteria:

1. History of any pancreatic or biliary disease (eg. Familial colorectal cancer
syndromes, Ulcerative colitis or Crohn's disease)

2. History of any acute or chronic illness that requires current medical therapy,
including active gastrointestinal conditions, that might interfere with drug
absorption

3. History of large bowel resection for any reason

4. Diagnosed narcotic or alcohol dependence

5. Women with childbearing potential who do not agree to practice effective birth
control.

6. Use of curcumin within the last 14 days

7. Allergy to study agent

8. Individuals with creatinine, AST or ALT above 1.5 times the upper limit of normal at
baseline.

9. Personal or inherited bleeding disorders or therapeutic anti-coagulation with
warfarin.

10. Women who are pregnant or nursing.