Inclusion Criteria

- INCLUSION CRITERIA:

- Patients must have a diagnosis of urothelial carcinoma of the bladder, urethra,
ureter, or renal pelvis, with histological confirmation at the Laboratory of
Pathology of the NCI, NIH.

- Patients must have progressive metastatic disease. Progressive disease will be
defined as new or progressive lesions on cross-sectional imaging. Patients must have
at least:

- One measurable site of disease (according to RECIST criteria) that has not been
previously irradiated. If the patient has had previous radiation to the marker
lesion(s), there must be evidence of progression since the radiation.

- Or, appearance of one new bone lesion.

- Patients must have been previously treated, as defined by the following:

- Treatment with at least one prior cytotoxic agent (which must have included at least
one of the following: cisplatin, carboplatin, paclitaxel, docetaxel, or gemcitabine),
administered in the perioperative or metastatic setting and may have been
administered sequentially (e.g., first-line treatment followed by second-line
treatment at time of progression) or as part of a single regimen.

- 18 years of age or older

- ECOG performance status of < 2 or Karnofsky Performance Status greater than or equal
to 60%

- Resolution of all acute toxic effects of prior chemotherapy, radiotherapy, or
surgical procedure to NCI CTCAE grade less than or equal to 1 or baseline

- Adequate organ function as defined by the following criteria:

- Serum aspartate transaminase (AST; serum glutamic oxaloacetic transaminase [SGOT])
and serum alanine transaminase (ALT; serum glutamic pyruvic transaminase [SGPT]) less
than or equal to 2.5 times the upper limit of normal (ULN); 5.0 times the ULN in
cases of liver metastases

- Total serum bilirubin less than or equal to 1.5 mg/dL (unless elevation from
Gilbert's disease or similar syndrome due to slow conjugation of bilirubin)

- Absolute neutrophil count (ANC) greater than or equal to 1000/microL

- Platelets greater than or equal to 100,000/microL

- Serum creatinine less than or equal to 2.0 mg/dl or calculated creatinine clearance
(CrCl) greater than or equal to 30 mL/min

- Hemoglobin > 9gm/dL

- PT, aPTT must be within normal range

- Patients on anticoagulants may be enrolled as long as the INR does not exceed 3.

EXCLUSION CRITERIA:

- Receipt of an investigational agent within 4 weeks prior to first dose with TRC105

- Major surgery including open biopsy or systemic therapy < 4 weeks prior to first
dose with TRC105

- Radiation therapy (except small field) < 3 weeks prior to first dose with TRC105

- Small field radiation therapy < 2 weeks prior to first dose with TRC105

- Minor surgical procedures within 2 weeks

- Uncontrolled chronic hypertension (systolic > 140 or diastolic > 90mm Hg despite
optimal therapy)

- Brain metastasis, or leptomeningeal disease because of their poor prognosis and
because they often develop progressive neurologic dysfunction that would confound the
evaluation of neurologic and other adverse events.

- Unstable angina, MI, symptomatic congestive heart failure, cerebrovascular accident,
transient ischemic attack, arterial embolism, pulmonary embolism, DVT, PTCA or CABG
within the past 6 months

- Cardiac arrhythmias of NCI CTCAE grade greater than or equal to 2 within the last
month

- Serious, non-healing wound, ulcer, or bone fracture

- Known active hepatitis

- Hemorrhage within 30 days of dosing or history of persistent gross hematuria

- Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)
related illness

- History of hypersensitivity reaction to human or mouse antibody products

- Pregnancy or breastfeeding. Female patients must be surgically sterile (i.e.:
hysterectomy) or be postmenopausal, or must agree to use effective contraception
during the study and for 3 months following last dose of TRC105. All female patients
of reproductive potential must have a negative pregnancy test (serum) within 7 days
prior to first dose. Male patients must be surgically sterile or must agree to use
effective contraception during the study and for 3 months following last dose of
TRC105. The definition of effective contraception will be based on the judgment of
the Principal Investigator or a designated associate.

- Other severe acute or chronic medical or psychiatric condition, or laboratory
abnormality that may increase the risk associated with study participation or study
drug administration, or may interfere with the interpretation of study results, and
in the judgment of the Investigator would make the patient inappropriate for entry
into this study

- History of peptic ulcer disease, unless a subsequent endoscopy has confirmed complete
resolution of the ulcer

- History of acquired or inherited hypocoagulopathies (bleeding risk), including but
not limited to hereditary hemorrhagic telangiectasis.