Inclusion Criteria:

- Histologically or cytologically confirmed adenocarcinoma of the prostate.

- Undergone definitive treatment (surgery, surgery with radiation therapy, cryotherapy,
radiation therapy or brachytherapy) for the primary prostate tumor.

- Rising PSA on a minimum of 3 time points (including screening psa) within the 12
months prior to study initiation.

- > 18 years of age.

- Life expectancy of greater than 6 months.

- ECOG performance status 0, 1 or 2.

- Testosterone level of ≥1.5 ng/mL at screening.

- Adequate kidney, liver and bone marrow function

- Agrees to abstain from other commercially available MP products while participating
in this study.

- Subject's use of other dietary/herbal supplements (e.g. saw palmetto, selenium, etc)
has been stable for at least 2 months prior to screening and the subject agrees not
to stop or change the dose(s) while participating in the study.

- Signed a written informed consent document and agrees to comply with requirements of
the study.

Exclusion Criteria:

- Known radiographic evidence of metastatic disease, except for presence of positive
lymph nodes from the surgical pathology. Pelvic/intraperitoneal lymph nodes less than
2.0 cm maybe considered nonspecific and the patient would be eligible

- Receipt of any therapies that modulate testosterone levels (e.g., androgen
ablative/anti-androgen therapy, 5 alpha reductase inhibitors) for a minimum of 6
months prior to study

- Prior or concomitant treatment with experimental drugs, high dose steroids, or any
other cancer treatment within 4 weeks prior to the first dose of the study product

- Consumption of Muscadine Plus over the past 2 months

- Known allergy to muscadine grapes or ellagic acid

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements

- Negative PSA doubling time (1 time point may be excluded per 3e inclusion criteria)