Airway Epithelium Gene Expression in the Diagnosis of Lung Cancer: AEGIS I

Inclusion Criteria:

1. The patient is being evaluated for the diagnosis of possible lung cancer or "rule out
lung cancer" and is indicated for bronchoscopy.

2. The patient is undergoing bronchoscopy

3. ≥ 21 years of age

4. Patient meets local site's standard of care (SOC) for performing diagnostic
bronchoscopy

5. The patient is a current or former cigarette smoker (defined as having smoked >100
cigarettes in their lifetime.

Exclusion Criteria:

1. The Pulmonary physician does not recommend that bronchoscopy be performed

2. The patient is unable to be consented into the study or unable to comply with
requirements of the study

3. The patient has previously been diagnosed with primary lung cancer

4. Immediately prior to bronchoscopy, the patient has been on a mechanical ventilator
for ≥ 24 consecutive hours.