Obesity-related Mechanisms and Mortality in Breast Cancer Survivors

Inclusion Criteria:

- BMI at least 25.0 kg/m2

- Diagnosed with Stage I, II, or III breast cancer within past 5 years

- Treatment with total mastectomy or breast-sparing surgical removal of cancer with
clear macroscopic margins, and axillary dissection, followed by adjuvant breast
radiation

- Not scheduled for or currently undergoing chemotherapy

- Accessible geographically and by telephone

- Able to communicate dietary and physical activity data via telephone

- If taking statins, tamoxifen, or aromatase inhibitors; able and willing to remain on
treatment for 6-month study period

- Post-menopausal at diagnosis

Exclusion Criteria:

- Preliminary bloodwork outside of specified ranges

- Evidence of renal insufficiency, liver disease, or congestive heart failure

- Currently taking corticosteroid pills or steroid hormone therapy (including vaginal
estrogen creams)

- Recent initiation (< 3 months ago) of thiazides or β-blockers

- Taking insulin or other antidiabetic drug

- Other primary or recurrent invasive cancer in past 10 years

- Unable to commit to study requirements