KIR Genotyping for Unrelated Donor (URD) Selection Prior to Hematopoietic Cell Transplantation (HCT) for AML: Selecting a Favorable KIR Donor
Transplant Centers will select the best HLA matched, and as appropriate, preferred KIR
donor.
Interventional
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Incidence of Relapse
To measure the impact of donor selection for KIR genotype in allogeneic URD HCT for AML on cumulative incidence of relapse. We will determine a quantitative estimate of the likelihood of better KIR donors identified with routine, non-directed donor selection along with KIR genotyping data. The observed incidence of success in a better KIR donor identified within 8 weeks will be compared to the original donor genotype expected frequencies identified in our retrospective genotyping of 1086 donors selected for AML transplants.
2 Years
No
Daniel Weisdorf, M.D.
Principal Investigator
Masonic Cancer Center, University of Minnesota
United States: Institutional Review Board
2010LSUC043
NCT01288222
March 2011
August 2014
Name | Location |
---|---|
Roswell Park Cancer Institute | Buffalo, New York 14263 |
Fred Hutchinson Cancer Research Center | Seattle, Washington 98109 |
Mayo Clinic Cancer Center | Rochester, Minnesota 55905 |
Washington University School of Medicine | Saint Louis, Missouri 63110 |
Hackensack University Medical Center | Hackensack, New Jersey 07601 |
University of Pennsylvania | Philadelphia, Pennsylvania 19104 |
Emory University | Atlanta, Georgia 30322 |
Cleveland Clinic | Cleveland, Ohio 44195 |
M.D. Anderson Cancer Center | Houston, Texas 77030 |
Masonic Cancer Center, University of Minnesota | Minneapolis, Minnesota 55455 |
Indiana University Simon Cancer Center | Indianapolis, Indiana 46202 |
Baylor Sammons Cancer Center | Dallas, Texas 75246 |
Mayo Clinic - Scottsdale | Scottsdale, Arizona 85259 |
Colorado Blood Cancer Institute | Denver, Colorado 80218 |
Ohio State University Comprehensive Cancer Center | Columbus, Ohio |
Kansas University Cancer Center | Kansas City, Kansas 66160 |
New York Presbyterian Weill Cornell Medical Center | New York, New York 10021 |
University of Chicago Medical Center Cancer Center | Chicago, Illinois 60637 |
Methodist Healthcare System of San Antonio | San Antonio, Texas 78229 |