Inclusion Criteria:

- Participants must have clinical diagnosis of lung or bladder cancer. Platinum-based
chemotherapy must be planned either for neoadjuvant chemotherapy for Stage II or
above bladder cancer, or palliative therapy for stage IV lung or bladder cancer no
matter whether patients participate in this study or not. Patients with Stage IV lung
or bladder cancer must have measurable lesion(s).

- Prior radiation or surgery is allowed, but should be finished at least 2 weeks prior
to study enrollment. If a participant has prior radiation therapy, at least one
measurable lesion outside of the radiation field should be available for the
evaluation of response to chemotherapy.

- Participants must be 18 years or older. We do not see any patients with NSCLC or
bladder TCC are diagnosed under the age of 18 years.

- ECOG performance status equal or less than to 2 (Karnofsky equal to or greater than
50%).

- Life expectancy of at least 3 months.

- Participants must have normal organ and marrow function as defined below: Absolute
neutrophil count greater than/equal to 1,500/microL; Platelet count greater
than/equal to 100,000/microL; Total bilirubin less than 1.5 X ULN; AST (SGOT) less
than/equal to 2.5 X ULN; Creatinine less than 1.5 X ULN

- Women of child-bearing potential and men must agree to use adequate contraception
(hormonal or barrier method of birth control; abstinence) prior to study entry and
for 30 days after study participation.

- Ability to understand and willing to sign a written informed consent document.

Exclusion Criteria:

- Participants may not be receiving any other investigational agents.

- Patients must not receive concomitant radiation with chemotherapy if they do not have
any measurable lesions outside of the radiation field.

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements.

- Participants who are pregnant or nursing.

- Participants who are allergic to platinum agents.

- Participants who receive chemotherapy before that includes cisplatin, carboplatin or
oxaliplatin.