Inclusion Criteria:

- Must report cognitive difficulties of 3 or higher on a 0-10 scale

- Must provide informed consent

- Be able to read English

- Have a primary diagnosis of cancer

- Be able to swallow medication

- Women of child-bearing potential must not be pregnant or become pregnant during the 6
week study

- Agree not to take NSAIDs during the 6 week intervention period

- Be scheduled to receive an additional 3 cycles of adjuvant chemotherapy or multiple
cycles over a 42-day period

- Must have the approval of their treating physician to begin the exercise program and
receive the ibuprofen

- Must be over 18 years of age

Exclusion Criteria:

- Currently taking a consistent dosage of a NSAID at least 3 days a week for the last 3
months

- Have an allergy to NSAIDs

- Be identified as in active or maintenance stage of exercise behavior as assessed by
the single-item exercise stages of change short form

- have physical limitations that contraindicate participation in sub-maximal
physiological fitness testing or a low to moderate home-based walking and progressive
resistance program

- have a history of peptic ulcer disease within the last 12 months

- Diagnosed with a neurodegenerative disease

- Had a myocardial infraction within the past 6 months

- Patients with a neutropenic episode during the first cycle of chemotherapy or at high
risk for a neutropenic episode during future chemotherapy cycles at the treating
physicians discretion

- Have confirmed metastatic disease to the central nervous system

- Have been diagnosed with a major psychiatric illness within the last 5 years