An Open-label, Randomized, Multi-center, Phase III Study to Compare the Safety and Efficacy of Dovitinib Versus Sorafenib in Patients With Metastatic Renal Cell Carcinoma After Failure of Anti-angiogenic (VEGF-targeted and mTOR Inhibitor) Therapies
Interventional
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
To compare Progression Free Survival (PFS) in Dovitinib and Sorafenib Groups (central radiology assessment)
Until disease progression or discontinuation of treatment due to unacceptable toxicity
No
Novartis Pharmaceuticals
Study Director
Novartis Pharmaceuticals
United States: Food and Drug Administration
CTKI258A2302
NCT01223027
March 2011
May 2013
Name | Location |
---|---|
The West Clinic | Memphis, Tennessee 38120 |
Kaiser Permanente Hawaii | Honolulu, Hawaii 96819 |
Northeast Georgia Cancer Care | Athens, Georgia 30607 |
Cancer Centers of the Carolinas CC of C -Eastside | Greenville, South Carolina 29605 |
Rocky Mountain Cancer Centers RMCC - Denver-Midtown | Greenwood Village, Colorado |
Highlands Oncology Group Dept of Highlands Oncology Grp | Fayetteville, Arkansas 72703 |
New York Oncology Hematology, P.C. Dept. of New York Oncology. PC | Troy, New York 12180 |
Cedars Sinai Medical Center Cedars Sinai Medical Ctr. (SC) | Los Angeles, California 90048 |
Comprehensive Cancer Centers of Nevada CCC of Nevada (1) | Las Vegas, Nevada 89109 |
Florida Cancer Specialists DeptofFloridaCancerSpecialists | Fort Myers, Florida 33901 |
St. Luke's Hospital and Health Network St Luke's | Bethlehem, Pennsylvania |
University of California San Diego Dept of Moores Cancer Ctr (5) | La Jolla, California 92093-0658 |
Straub Clinic & Hospital Straub | Honolulu, Hawaii 96813 |
University of Kansas Cancer Center Univ of KS | Kansas City, Kansas 66160 |
University of Maryland Medical Center UMMC | Baltimore, Maryland 21201 |
Wayne State University/Karmanos Cancer Institute Dept.of KarmanosCancerInst (5) | Detroit, Michigan 48201 |
University of Minnesota Medical Center - Fairview Univ of MN | Minneapolis, Minnesota 55455 |
CINJ at Cooper University Hospital Cooper | Voorhees, New Jersey 08043 |
Memorial Sloan Kettering Cancer Center Dept. of MSKCC | New York, New York 10021 |
SUNY - Upstate Medical University Div. of Hematology-Oncology | Syracuse, New York 13210 |
Willamette Valley Clinical Studies Williamette Valley Cancer | Eugene, Oregon 97404 |
Medical University of South Carolina Med Univ SC | Charleston, South Carolina 29425 |
Vanderbilt University Medical Center SC | Nashville, Tennessee 37232 |
Texas Oncology, P.A. Texas Oncology - Houston | Dallas, Texas 75251 |
University of Texas Southwestern Medical Center UTSW | Dallas, Texas 75390-9034 |
Texas Oncology, P.A. Texas Onc - Austin | Dallas, Texas 75251 |
Deke Slayton Cancer Center c/o Study Coordinator | Webster, Texas 77598 |
Utah Cancer Specialists Dept.of Utah Cancer Spec. (3) | Salt Lake City, Utah 84103 |
University of Virginia Health Systems Univ Virginia | Charlottesville, Virginia 22908-0334 |
Rockwood Clinic Spokane Location | Spokane, Washington 99202 |
University of California at Los Angeles UCLA (4) | Los Angeles, California 90095 |
Stanford University Medical Center Cancer Clinical Trials Office | Stanford, California 94304 |
Sarah Cannon Research Institute SC - 3 | Chattanooga, Tennessee 37404 |
Baylor College of Medicine Dept. of Sammons Cancer (4) | Dallas, Texas 75246 |