Inclusion Criteria:

- Either 1. Established primary lung cancer/ cancer metastatic to lung,
OR 2. Lesion suspicious for malignancy in lung, according to the following criteria:

A. Histopathologically confirmed lung cancer or cancer metastatic to lung, OR B. Plan for
biopsy of suspicious lung mass based on imaging (growth on serial CT scan or nodule/mass
with focal hypermetabolism on FDG-PET scan), OR C. Known metastatic cancer, with
metastases to the lung based on imaging

- Age > 18 years old

- Eastern Clinical Oncology Group performance status 0, 1 or 2 (Appendix IV)

- No prior surgery, chemotherapy, or radiation for the current lung tumor

- Both men and women and members of all races and ethnic groups are eligible for this
trial.

Exclusion Criteria:- Prior radiotherapy to thorax

- Allergy to iodine

- Contraindication to receiving radiotherapy, unless undergoing surgery

- Women who are pregnant