Assessing Fertility Potential in Female Cancer Survivors

Inclusion Criteria

Inclusion Criteria for cancer survivors:

- Previous treatment with chemotherapy and/or radiation therapy for either cancer
or another illness.

- Age between 15-40 years.

- Post-menarchal.

- Presence of a uterus and at least one ovary.

- Ability and willingness to comply with stuy protocol.

- Have given written informed consent, prior to any study-related procedure, not part
of normal medical care, with the understanding that consent may be withdrawn by the
patient at any time without prejudice to their future medical care.

Inclusion Criteria for controls:

- Healthy females who have never been treated for cancer.

- Age between 15 and 50 years.

- Post-menarchal with regular cyclic menses (every 21-35 days)

- Presence of a uterus and at least 1 ovary.

- Ability and willingness to comply with study protocol.

- Have given written informed concent, prior to any study-related procedure, not part
of normal medical care, with the understanding that consent may be withdrawn by the
patient at any time without prejudice to their future medical care.

Exclusion Criteria:

- Current pregnancy.

- Use of hormonal contraception or use of hormone replacement therapy within the
previous 4 weeks.

- Lactation within the previous 3 months.

- Chronic illness that would limit ability of participant to comply with study
protocol.

- Any known medical condition, other than cancer, which in the judgement of the
investigator is known to be associated with premature ovarian failure (such as
Turner's Syndrome or Fragile X) or ovulatory dysfunction (such as thyroid disease,
adrenal dysfunction, Cushing's syndrome, hyperprolactinemia, and polycystic ovarian
syndrome).

- For controls, a history of infertility.

Additional inclusion criteria for clomiphene citrate sub-study:

- Age between 18 and 42 years.

Additional exclusion criteria for the clomiphene citrate sub-study:

- Known allergy or hypersensitivity to clomiphene citrate.

- History of liver dysfunction.

- Abnormal uterine bleeding.

- Ovarian cysts