Combined Exercise Program for Early Breast Cancer Survivors

Inclusion Criteria:

- Newly diagnosed (I-III) with a first primary invasive breast cancer

- Have undergone a lumpectomy or mastectomy

- Have completed neoadjuvant/adjuvant chemotherapy and able to initiate Exercise
program (if randomized to that arm) within 12 weeks of therapy completion

- Body mass index (BMI) > 25 kg/m^2 or body fat > 30% (determined by Dr.
Dieli-Conwright at baseline visit)

- Currently participate in less than 60 minutes of physical activity per week May use
adjuvant endocrine therapy if use will be continued for duration of study period

- Nonsmokers (i.e., not smoking during previous 12 months)

- Willing to travel to the exercise facility and USC

- Able to provide physician clearance to participate in exercise program

- Women of all racial and ethnic backgrounds will be included in the study enrollment
process

Exclusion Criteria:

- History of chronic disease including diabetes, uncontrolled hypertension or thyroid
disease

- Weight reduction >= 10% within past 6 months

- Diagnosed with human epidermal growth factor receptor 2 (HER2)-positive tumor
(exclusion due to patient use of Herceptin medication for 1 year following
chemotherapy)

- Metastatic disease

- Planned reconstructive surgery with flap repair during trial and follow-up period

- Cardiovascular, respiratory or musculoskeletal disease or joint problems that
preclude moderate physical activity