Inclusion Criteria:

A. Common to All Indications:

- Life expectancy at least 12 weeks

- ECOG Performance Status of 0-2

B. For Acute myelogenous leukemia (AML) Subjects:

- First Relapse and primary induction failure in AML (M3 excluded)

- Secondary AML subjects from myelodysplastic syndrome (MDS) or prior chemotherapy are
eligible. MDS-only subjects are not eligible

C. For Follicular Lymphoma (FL), Diffuse Large B-Cell Lymphoma (DLBCL) Subjects:

- Must be at least 4 weeks (for FL) or 2 weeks (for DLBCL) since prior cytotoxic,
biologic, monoclonal antibody, or investigational therapy

- Ability to undergo tumor biopsy pre-treatment and at end of monotherapy period
(though not mandatory for all subjects)

- Subjects must have a histologically confirmed diagnosis of relapsed or refractory
disease

D. For Chronic lymphocytic leukemia (CLL) Subjects:

- Subjects must have a histologically confirmed diagnosis of relapsed or refractory
disease

- Must be at least 4 weeks since prior cytotoxic, biologic, monoclonal antibody, or
investigational therapy, including corticosteroids

Exclusion Criteria:

A. Common to All indications:

- Prior anti-CXCR4 therapy including BMS-936564 (MDX-1338)

- Less than 3 months from prior hematopoietic stem cell transplant

- Presence of active graft versus host disease

B. For AML Subjects:

- Acute promyelocytic leukemia (M3)

- Left ventricular ejection fraction < institutional limits of normal

C. For FL, DLBCL Subjects:

- (For DLBCL): Inadequate renal function defined as creatinine clearance (by
Cockcroft-Gault formula) < 60 mL/min

- Major surgery, not related to debulking procedures, within 21 days of first dose

- Myocardial infarction within 6 months prior to screening or Class III or IV heart
failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, or
electrocardiographic evidence of acute ischemia

- Myelodysplastic syndrome (MDS)

D. For CLL Subjects:

- No progression to more aggressive B-cell cancers, such as Richter's syndrome

- Major surgery within 21 days of Cycle 1, Day 1. Patients undergoing debulking
procedures and minor surgery are allowed after a recovery period, in the judgment of
the Investigator

- Myocardial infarction within 6 months prior to screening Class III or IV heart
failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, or
electrocardiographic evidence of acute ischemia