Childhood Cancer Survivor Study
N/A
N/A
Both
Cancer
Trial Information
Childhood Cancer Survivor Study
The study will focus on the following objectives:
- Characterize survivors' health with respect to disease- and treatment-related factors.
- Investigate the consequences of various intensities of exposure to chemotherapy and/or
radiation on health outcomes (e.g., cardiovascular, reproductive, second cancers,
etc…).
- Compare the mortality experience of survivors with the general population.
- Characterize the health-related behaviors, patterns of medical care, and medical
follow-up needs of survivors.
- Describe patterns of familial aggregation of cancer, including known (and variations
of) cancer family syndromes.
- Collect and store biologic samples (saliva, blood, second tumor tissue) to correlate
with health outcomes and use for future research.
Inclusion Criteria:
Initial Cohort:
- Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor,
Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between
January 1, 1970 and December 31, 1986 at one of participating centers.
Expanded cohort:
- Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor,
kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January
1, 1987 and December 31, 1999 at one of participating centers.
- English- or Spanish-speaking and living in the U.S. or Canada at the time of
diagnosis.
Exclusion Criteria:
- Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma,
craniopharyngioma, etc.) treated with radiation and/or chemotherapy.
- Non-English speaking or residence outside the US or Canada.
Sibling Controls:
- For comparison purposes, a group of sibling controls will be identified to represent
a stratified random sample based on the distribution of survivors with regard to
cancer diagnosis, age, sex, race, and geographic location.
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Retrospective
Outcome Measure:
To characterize survivors' health outcomes with respect to disease-, treatment, and genetic-related factors.
Outcome Time Frame:
25 years
Safety Issue:
No
Principal Investigator
Les Robison, Ph.D
Investigator Role:
Principal Investigator
Investigator Affiliation:
St. Jude Children's Research Hospital
Authority:
United States: Institutional Review Board
Study ID:
CCSS
NCT ID:
NCT01120353
Start Date:
March 1994
Completion Date:
March 2019
Related Keywords:
- Cancer
- Childhood cancer
- Young Children
- Adults
Name | Location |
|---|---|
| Roswell Park Cancer Institute | Buffalo, New York 14263 |
| Children's Hospital of Philadelphia | Philadelphia, Pennsylvania 19104 |
| Dana-Farber Cancer Institute | Boston, Massachusetts 02115 |
| Children's Hospital Los Angeles | Los Angeles, California 90027-0700 |
| Children's National Medical Center | Washington, District of Columbia 20010-2970 |
| Children's Hospital of Pittsburgh | Pittsburgh, Pennsylvania 15213 |
| City of Hope National Medical Center | Los Angeles, California 91010 |
| Nationwide Children's Hospital | Columbus, Ohio 43205-2696 |
| Stanford University School of Medicine | Stanford, California 94305-5317 |
| University of Minnesota | Minneapolis, Minnesota 55455 |
| University of California-San Francisco | San Francisco, California 94143 |
| M.D. Anderson Cancer Center | Houston, Texas 77030 |
| University of Texas Southwestern Medical Center | Dallas, Texas |
| Texas Children's Hospital | Houston, Texas |
| Memorial-Sloan Kettering Cancer Center | New York, New York 10021-6007 |
| Seattle Children's Hospital | Seattle, Washington 98105 |
| University of California-Los Angeles | Los Angeles, California 90095 |
| Indiana University/Riley Hospital for Children | Indianapolis, Indiana 46202 |
| St . Jude Children's Research Hospital | Memphis, Tennessee 38105 |
| University of Alabama at Birmingham/Children's of Alabama | Birmingham, Alabama 35294 |
| Children's Hospital Colorado | Aurora, Colorado 80045 |
| Emory University/Children's Health Care of Atlanta | Atlanta, Georgia 30322 |
| University of Michigan/Mott Children's Hospital | Ann Arbor, Michigan 48109 |
| Children's Hospitals & Clinics of Minnesota | Minneapolis, Minnesota 55404 |
| St. Louis Children's Hospital/The Washington University | St. Louis, Missouri 63130 |
