Biobehavioral Influences and the Ovarian Tumor Microenvironment

Inclusion Criteria:

- Patients with a histologic diagnosis of epithelial ovarian cancer, primary peritoneal
carcinoma, or fallopian tube cancer; FIGO stage I to IV defined surgically at the
completion of the initial abdominal surgery and with appropriate tissue available for
histologic evaluation.

- Patients with the following histologic epithelial cell types are eligible: serous
adenocarcinoma, endometrioid adenocarcinoma, mucinous adenocarcinoma,
undifferentiated carcinoma, clear cell carcinoma, mixed epithelial carcinoma, or
adenocarcinoma not otherwise specified. However, the histologic features must be
compatible with primary Mullerian epithelial adenocarcinoma.

- GOG performance status 0-3

Exclusion Criteria:

- Patients with a diagnosis of borderline epithelial ovarian tumor (formerly: tumors of
low malignant potential" or recurrent invasive epithelial ovarian, primary
peritoneal, or fallopian tube cancer treated with chemotherapy or radiotherapy
previously are excluded.

- Patients who received neoadjuvant chemotherapy for ovarian, primary peritoneal, or
fallopian tube carcinoma are excluded.

- Non-epithelial ovarian cancers or metastases to the ovaries from organs are excluded.

- Previous cancer diagnosis except for basal cell carcinoma of the skin or history of
lymphoma.

- Pregnancy or age <18 years old

- Use of systemic glucocorticoids such as prednisone or decadron in the last 30 days

- Comorbid conditions: Addison's disease, autoimmune hepatitis, hepatitis B, hepatitis
C, AIDS or HIV, lupus erythematosus, mixed connective tissue disease, rheumatoid
arthritis.

- Inability to accurately answer questions (e.g. a condition such as dementia)