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Protocol to Obtain Blood for Discovery of Novel Biomarkers and Potential Therapeutic Targets in Chronic Lymphocytic Leukemia


N/A
18 Years
N/A
Not Enrolling
Both
Chronic Lymphocytic Leukemia

Thank you

Trial Information

Protocol to Obtain Blood for Discovery of Novel Biomarkers and Potential Therapeutic Targets in Chronic Lymphocytic Leukemia


The blood sample will be used in the laboratory to perform focused studies on Chronic
Lymphocytic Leukemia (CLL).


Inclusion Criteria:



- Patients undergoing routine blood draws as part of their ongoing follow-up care for
CLL at the Norris Cotton Cancer Center of DHMC.

- Normal donors who have no history of active or prior hematologic malignancy.

Exclusion Criteria:

- Patients who have received cytotoxic drug, oral or intravenous steroid or targeted
antibody therapy for their CLL, other hematologic malignancy or other disease process
within the past 2 months are excluded. Use of intravenous immunoglobulin (IVIg) is
not a reason for exclusion.

- Normal donors who have a history of steroid use, immunosuppression therapy or
autoimmune disease are excluded.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

To identify the genes that are differentially expressed at the polysomal RNA and protein levels in human patient CLL cells (compared to normal donor lymphocytes) using high-throughput microarray approaches.

Outcome Time Frame:

2 Years

Safety Issue:

No

Principal Investigator

Christopher H Lowrey, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Dartmouth-Hitchcock Medical Center

Authority:

United States: Institutional Review Board

Study ID:

D1019

NCT ID:

NCT01069432

Start Date:

May 2010

Completion Date:

February 2011

Related Keywords:

  • Chronic Lymphocytic Leukemia
  • Chronic Lymphocytic Leukemia
  • CLL
  • Normal Volunteers
  • Leukemia
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Lymphoid

Name

Location
Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire  03756