A Phase I Dose-Escalation Trial of Biweekly Intraperitoneal Oxaliplatin With Systemic Capecitabine and Bevacizumab Following Cytoreduction in Patients With Peritoneal Carcinomatosis From Appendiceal or Colorectal Cancer

Inclusion Criteria:

- Patients must fulfill (or have previously met) the following eligibility requirements
prior to initiation of chemotherapy:

- Histological Diagnosis: Patients must have a histologically documented peritoneal
carcinomatosis from either colorectal or appendiceal adenocarcinoma.

- Prior Surgical Debulking and Port Placements: Patients must have undergone debulking
surgery with peritonectomy and placement of intraperitoneal ports and have been
allowed at least 4 weeks to recover prior to receiving chemotherapy.

- Active port: Patients must undergo a peritoneal scan documenting at least one
working intraperitoneal port prior to receiving chemotherapy.

- Patients may have received prior chemotherapy.

- Age: Patients must be ≥18 years of age. Because no dosing or toxicity data are
currently available on the use of oxaliplatin in patients <18 years of age.

- Performance Status: (Eastern cooperativeOncology Group) ECOG 0-2.

- Recovery from Intercurrent Illness: Patients must have recovered from uncontrolled
intercurrent illness including, but not limited to, ongoing or active infection,
symptomatic congestive heart failure, unstable angina pectoris, or cardiac
arrhythmias.

- Inclusion of Women and Minorities: Entry to this study is open to both men and women
and to all racial and ethnic subgroups.

- Informed Consent: All patients must be consented prior to chemotherapy. The patient
should not have any serious medical of psychiatric illness that would prevent either
the giving of informed consent or the receipt of treatment.

- Hematological Status: absolute neutrophil count ≥1,500/mm³, platelet count
≥100,000/mm³, and hemoglobin ≥8 g/dl.

- Hepatic function: Total bilirubin must be <2X the institutional upper limit of normal
(ULN); Transaminases (SGOT and/or SGPT) must be ≤3X the institutional upper limit of
normal (ULN; Alkaline phosphatase must be ≤4X the institutional upper limit of normal
(ULN)

- Renal Function: Patients must have adequate renal function prior to chemotherapy
defined as serum creatinine ≤ 2.0 mg/dl or creatinine clearance ≥60 ml.min/1.73 m²
for patients with creatinine levels above 2.0 mg/dl.

Exclusion Criteria:

- Pregnant or breast feeding: For all sexually active patients, the use of adequate
contraception (hormonal or barrier method of birth control) will be required during
therapy, prior to study entry, and for the duration of study participation.
Non-pregnant status will be determined in all women of childbearing potential.

- Prior history of hypersensitivity reactions to oxaliplatin, bevacizumab, 5-FU or
capecitabine.

- Gastrointestinal ailments that may alter the absorption of oral medications (i.e.
bowel obstruction, short-gut syndrome).

- Patients receiving antiretroviral therapy Highly Active Anti Retroviral Treatment
(HAART) for HIV infection are excluded from the study because of possible
pharmacokinetic interactions. Appropriate studies will be undertaken in patients
receiving HAART therapy, when indicated.

- Patients with Grade 2 or higher peripheral neuropathy.