OXC401-PO1s/WVU 1309 - A Pilot Study of Fosbretabulin With Bevacizumab in Recurrent High-Grade Gliomas

Inclusion Criteria:

1. Patients must have histologically or cytologically confirmed grade III Anaplastic
gliomas (including anaplastic astrocytoma, anaplastic oligodendroglioma, and
anaplastic oligoastrocytoma) or Grade IV Glioblastoma multiforme.

2. Recurrence or progression after failing first line treatment of temozolomide
chemotherapy and radiation. Patient who failed additional lines of treatment are
eligible for participating in the trial. Patients must have measurable disease,
defined as having contrast enhancing measurable disease on MRI of brain. Baseline MRI
should be done no more than 2 weeks from starting treatment.

3. At least 4 weeks since prior chemotherapy or radiation therapy, 4 weeks if the last
regimen included BCNU.

4. Age greater than 18 years. Because no dosing or adverse event data are currently
available on the use of fosbretabulin in combination with bevacizumab in patients
less than 18 years of age, children are excluded from this study.

5. Life expectancy of greater than 3 months.

6. ECOG performance status 0-2 Karnofsky greater than 60%).

7. Patients must have normal organ and marrow function as defined.

8. The effects of fosbretabulin on the developing human fetus at the recommended
therapeutic dose are unknown. For this reason and because vascular disrupting agents
as well as other therapeutic agents used in this trial are known to be teratogenic,
women of child—bearing potential and men must agree to use adequate contraception
(hormonal or barrier method of birth control; abstinence) prior to study entry and
for the duration of study participation. Should a woman become pregnant (including
female partners of male study participants) or suspect she is pregnant while
participating in this study, she should inform the Investigator and her treating
physician immediately.

9. Ability to understand and the willingness to sign a written informed consent
document.

Exclusion Criteria:

1. Patients who have had chemotherapy or radiotherapy within 4 weeks prior to entering
the study or those who have not recovered from adverse events due to agents
administered more than 4 weeks earlier.

2. Patients with prior treatment using bevacizumab.

3. Patients should not have received any other investigational agents within 4 weeks.

4. History of abdominal fistula, GI perforation or intra-abdominal abscess within the
last 6 months.

5. Coagulopathy or bleeding diathesis. Patients on therapeutic dose of anticoagulation
are excluded from the study.

6. Uncontrolled intercurrent illness including, but not limited to, ongoing active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements. Also, MI/unstable angina within 6 months; stroke/TIA within 1
year; symptomatic claudication within 1 year; abnormalities on ECG including
prolonged QTc interval (i.e. > 450 ms for males and > 470 ms for females), new
Q-wave, RBBB, LBBB,ST-segment depression.

7. Grade 3 proteinuria (> 3.5 g protein/24 hours)

8. Uncontrolled hypertension (blood pressure >150/100 during Screening)

9. Clinically significant peripheral vascular disease.

10. History of allergic reactions attributed to compounds of similar chemical or biologic
composition to fosbretabulin or other agents used in the study.

11. Since dilantin induces the P450 system and the effect this will have on fosbretabulin
or bezvacazimab is not known, patients that are on seizure prophylaxis with dilantin
will not be eligible. Switching the seizure prophylaxis to noninducers of the P450
system such as levetiracetam is acceptable. Patients must be off dilantin for one
week before starting this clinical trial. Additionally fosbretabulin has the
potential to interact with drugs metabolized by CYP2C19 which includes barbiturates,
diazepam and valproic acid. However the clinical significance of these interactions
is not known.

12. Pregnant women are excluded from this study because fosbretabulin is a vascular
disrupting agent with the potential for teratogenic or abortifacient effects. Because
there is an unknown but potential risk for adverse events in nursing infants
secondary to treatment of the mother with fosbretabulin, breastfeeding should be
discontinued if the mother is treated with fosbretabulin.

13. HIV-positive patients on combination antiretroviral therapy are ineligible Because of
the potential for pharmacokinetic interactions with fosbretabulin. In addition,these
patients are at increased risk of lethal infections when treated with
marrowsuppressive therapy.