Clinical Study of Limonene in Women With a Recent Diagnosis of Early Stage Breast Cancer Electing to Undergo Excision Surgery
Inclusion Criteria:
- Women who are 18 years of age or older
- Women electing to undergo excision surgery for early stage breast cancer
- A minimum of 2 weeks from enrollment to definitive surgery
- Underwent core needle biopsy for breast cancer diagnosis
- No clinical evidence of metastatic breast cancer
- ECOG performance status 0-1
- Participants must have normal organ and marrow function
- Women of child-bearing potential must agree to use adequate contraception
- Ability to understand and the willingness to sign a written informed consent document
Exclusion Criteria:
- Concurrent chemotherapy or radiation therapy
- Use of selective estrogen receptor modifiers or aromatase inhibitors within the past
3 months or concurrently
- History of other malignancies within the past 5 years excluding non-melanoma skin
cancer and cancers confined to organs with removal as only treatment
- Participated in another clinical intervention trial within the past 3 months
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements
- Pregnant or breast-feeding women
- Use of dietary supplement that contains large amounts of d-limonene (such as
Heartburn Free with ROH10 and CoQ with d-limonene) within the past 3 months