Oral HPV Shedding and Oral Warts After Initiation of Antiretroviral Therapy
Oral HPV infection occurs at a higher rate among HIV-infected people than among the general
population. Recent research in the United States and Europe has also found that HIV-infected
people have a higher risk of oral and oropharyngeal squamous cell cancer than HIV-uninfected
people. In one study, it was found that HPV seropositivity was associated with an increased
risk of squamous cell carcinoma of the oropharynx (SCCOP). In addition to SCCOP, another
HPV-related health concern is oral warts, a condition for which there is no effective
treatment. Even after beginning treatment with highly active antiretroviral therapy (HAART),
active HPV replication in the mouth and oropharynx may persist in HIV-infected people,
leading to an increased risk of SCCOP and oral warts. The purpose of this study is to
evaluate the frequency of oral HPV DNA shedding and oral warts in HIV-infected people prior
to HAART initiation and at regular time points after HAART initiation.
ACTG A5257 is a study that is comparing the effectiveness of three non-nucleoside reverse
transcriptase inhibitor (NNRTI)-sparing HAART regimens in treatment-naïve participants. This
study will enroll participants from the ACTG A5257 study. Participants will attend a
baseline study visit at the same time as their ACTG A5257 baseline study visit. At baseline
and at Week 4, 16, 24, and 48 study visits, participants will undergo an examination of
their mouth, throat wash and saliva collection, and behavioral questionnaires. A blood
collection will also occur at Week 24.
Observational
Observational Model: Cohort, Time Perspective: Prospective
Type-specific oral HPV DNA shedding (presence versus absence)
Measured at baseline (measured at pre-entry and entry into A5257) and at Weeks 16 and 24
No
Caroline Shiboski, DDS, MPH, PhD
Study Chair
Department of Orofacial Sciences, UCSF AIDS OHARA
United States: Federal Government
ACTG A5272
NCT01029249
January 2010
May 2013
Name | Location |
---|---|
Stanford | Stanford, California 94305 |
Alabama Therapeutics CRS (5801) | Birmingham, Alabama 35294-2050 |
UCLA CARE Center CRS (601) | Los Angeles, California 90095 |
University of Southern California CRS (1201) | Los Angeles, California 90033 |
Ucsd, Avrc Crs (701) | San Diego, California 92103 |
University of California San Francisco AIDS CRS (801) | San Francisco, California 94110 |
University of Miami AIDS CRS (901) | Miami, Florida 33139 |
The Ponce de Leon Ctr. CRS (5802) | Atlanta, Georgia 30308 |
Rush University Medical Center (2702) | Chicago, Illinois 60612 |
Northwestern University CRS (2701) | Chicago, Illinois 60611 |
IHV Baltimore Treatment CRS (4651) | Baltimore, Maryland 21201 |
Beth Israel Deaconess Medical Center ACTG CRS (103) | Boston, Maryland 02215 |
Massachusetts General Hospital ACTG CRS (101) | Boston, Massachusetts 02114 |
Henry Ford Hosp. CRS (31472) | Detroit, Michigan 48202 |
Washington University CRS (2101) | St. Louis, Missouri 63110 |
Cooper Univ. Hosp. CRS (31476) | Camden, New Jersey 08103 |
New Jersey Medical School- Adult Clinical Research Ctr. CRS | Newark, New Jersey 07103 |
Cornell CRS (7804) | New York, New York 10011 |
HIV Prevention and Treatment | New York, New York 10032 |
University of Rochester ACTG CRS (1101) | Rochester, New York 14642 |
AIDS Care CRS (1108) | Rochester, New York 14607 |
University of North Carolina AIDS CRS | Chapel Hill, North Carolina 27514 |
Duke Univ. Med. Ctr. Adult CRS (1601) | Durham, North Carolina 27710 |
Moses H. Cone Memorial Hosp. CRS | Greensboro, North Carolina 27401 |
University of Cincinnati CRS | Cincinnati, Ohio 45267 |
MetroHealth CRS (2503) | Cleveland, Ohio 44109 |
Case CRS (2501) | Cleveland, Ohio 44106 |
The Ohio State University AIDS CRS (2301) | Colombus, Ohio 43210 |
Hospital of the University of Pennsylvania CRS (6201) | Philadelphia, Pennsylvania 19104 |
The Miriam Hospital ACTG CRS (2951) | Providence, Rhode Island 02906 |
Vanderbilt Therapeutics CRS (3652) | Nashville, Tennessee 37232 |
Houston AIDS Research Team CRS (31473) | Houston, Texas 77030 |
Virginia Commonwealth Univ. Medical Ctr. CRS (31475) | Richmond, Virginia 23219 |
University of Washington AIDS CRS (1401) | Seattle, Washington 98104 |