Inclusion Criteria:

- Advanced/metastatic solid tumors, for which no effective standard therapy exist

- Adult patients (age >/= 18)

- ECOG performance status (PS) 0 or 1

- Life expectancy of at least 3 months

- Adequate renal, liver function and bone marrow reserve

- Prior cancer therapy allowed, with max 4 regimens of chemotherapy. Washout: at least
4 wks (6 wks for nitrosoureas, mitomycin C and liposomal doxorubicin) and all
toxicities recovered to CTC Grade
- Prior radiotherapy allowed if no more than 25% of BM reserve irradiated

- Women and men of child producing potential should agree to use effective
contraception

- Capability to swallow capsules intact

Exclusion Criteria:

- Known uncontrolled/symptomatic brain metastases

- Currently active second malignancy

- Major surgery in the last 4 wks

- Any of the following in the past 6 months: myocardial infarction, unstable angina,
coronary/peripheral artery bypass graft, symptomatic congestive heart failure,
cerebrovascular accident or transient ischemic attack, pulmonary embolism, deep vein
thrombosis

- Pregnancy or breast-feeding women

- Known active infections

- History of drug allergic reactions

- Gastrointestinal disease or other malabsorption syndromes that would impact on drug
absorption.

- Documented gastrointestinal ulcer

- Other severe concurrent acute or chronic medical or psychiatric condition that could
compromise protocol objectives