Inclusion Criteria:

- PHASE I: Adult patients with histologically confirmed solid tumor malignancy that is
metastatic or unresectable and for which standard curative measures or other therapy
definitely capable of extending life expectancy does not exist

- PHASE II: All patients enrolled in the Phase II portion of this trial must have a
history of biopsy-proven ovarian or primary peritoneal cancer at Mayo Clinic, and
radiological evidence of recurrence at a previous site of disease, or biopsy
confirmation if the site represents a new site of disease; patients must have
received =< 2 prior therapeutic regimens and must be either refractory to
platinum-based therapy or have relapsed < 1 year after receiving a prior
platinum-based regimen

- Patients must have measurable disease with at least one lesion whose longest diameter
can be accurately measured as >= 2.0 cm with conventional techniques or as >= 1.0 cm
with spiral computed topography (CT); if spiral CT is used, it must be used for both
pre- and post- treatment tumor assessments

- Absolute neutrophil count >= 1500/mcL

- Hemoglobin >= 9.0 g/dL

- Platelets >= 100,000/mcL

- Total bilirubin =< 1.5x the upper limit of normal (ULN)

- Serum glutamic pyruvic transaminase (SGPT) (alanine aminotransferase [ALT]) or serum
glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) =< 2.5 x
ULN in the absence of hepatic metastasis; SGPT (ALT) =< 3 x ULN or SGOT (AST) =< 5 x
ULN in the presences of hepatic metastasis

- Creatinine =< 1.5 x ULN

- International normalized ratio (INR) =< 1.4 unless receiving therapeutic doses of
coumadin

- Partial thromboplastin time (PTT) =< 36 seconds

- Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0, 1, or 2

- Ability to provide informed consent

- Willingness to return to a Mayo Clinic institution for follow up

- Life expectancy >= 12 weeks

- Willingness to provide the biologic specimens is required by the protocol; this is
part of the mandatory translational research component; these specimens include:

- PHASE I: peripheral blood for plasma pharmacokinetic analysis and peripheral
blood mononuclear cell (PBMC) polymer assessment from 0-24 h after drug
administration on days 1 and 2 of cycle 1 as well as day 2 of cycle 2; urine for
assessment of ABT-888 renal clearance for 24 h after administration of drugs on
days 1 and 2 of cycle 1 as well as day 2 of cycle 2; and a pretreatment
peripheral blood sample for possible sequencing of the BRCA1, BRCA2 loci as well
as possible pharmacogenomic analysis

- PHASE II: all of the above samples plus a pretreatment biopsy for biological
studies and sequence analysis of the BRCA1 and BRCA2 loci

- Note: The goals of this study include assessment of the biologic effects on
surrogate markers of the agent(s) being tested and are, therefore, contingent
upon availability of the biologic specimens

- Women of childbearing potential only: Negative urine or serum pregnancy test done =<
7 days prior to registration

- Able to swallow and absorb the medication

Exclusion Criteria:

- Known standard therapy for the patient's disease that is potentially curative or
definitely capable of extending life expectancy

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements

- Any of the following prior therapies:

- Chemotherapy =< 4 weeks prior to registration

- Mitomycin C/nitrosoureas =< 6 weeks prior to registration

- Immunotherapy =< 4 weeks prior to registration

- Biologic therapy =< 4 weeks prior to registration

- Radiation therapy =< 4 weeks prior to registration

- Radiation to > 25% of bone marrow

- Investigational therapy or any ancillary therapy considered investigational
(utilized for a non-Food and Drug Administration [FDA]-approved indication and
in the context of a research investigation) =< 4 weeks prior to registration;
subjects with prostate cancer will be permitted to continue hormone therapy

- Failure to fully recover from acute, reversible effects of prior chemotherapy
regardless of interval since last treatment

- New York Heart Association classification III or IV

- Known central nervous system (CNS) metastases or seizure disorder; patients with
known brain metastases that have been successfully treated and stable for >= 6 months
without requirement for corticosteroids and without seizure activity will be eligible

- Any of the following, because this study involves both ABT-888, an investigational
agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and
newborn are unknown, and topotecan, an agent that has known genotoxic, mutagenic and
teratogenic effects:

- Pregnant women

- Nursing women

- Men or women of childbearing potential who are unwilling to employ adequate
contraception

- Co-morbid systemic illnesses or other severe concurrent disease which, in the
judgment of the investigator, would make the patient inappropriate for entry into
this study or interfere significantly with the proper assessment of safety and
toxicity of the prescribed regimens

- Immunocompromised patients (other than that related to the use of corticosteroids)
including patients known to be human immunodeficiency virus (HIV) positive

- Receiving any other investigational agent which would be considered as a treatment
for the primary neoplasm

- Other active malignancy, except non-melanotic skin cancer or carcinoma-in-situ of the
cervix; NOTE: If there is a history of prior malignancy, they must not be receiving
other specific treatment (other than hormonal therapy) for their cancer

- History of myocardial infarction =< 6 months, or congestive heart failure requiring
use of ongoing maintenance therapy for life-threatening ventricular arrhythmias

- More than 2 prior chemotherapy regimens for the current malignancy; full dose
chemotherapy used in conjunction with concurrent radiation therapy will be included
as prior therapy; NOTE: Prior hormonal therapy (e.g. leuprolide, aromatase
inhibitors, tamoxifen) will be allowed and not included as a prior chemotherapy