Trial Information

In Vivo Confocal Microscopy Tumor Atlas Study

Confocal endomicroscopy is a medical imaging modality that allows real‐time microscopy to be
performed on living tissue in vivo. The procedure involves a small endoscope which is placed
gently into contact with the tissue, providing significant in vivo magnification on a scale
similar to that obtained by the pathology laboratory microscope. It is already in clinical
use in the field of gastroenterological endoscopy, and investigational use in laparoscopy,
dermatology and gynecology. Further, in recent pilot studies endomicroscopy has also been
shown to be feasible in bronchoscopy, robot assisted prostatectomy and neurosurgery.The
study will use both endomicroscopy and biopsy to document the histological appearance of a
range of neurological tumour types and grades.

In subsequent analysis, the confocal image data and corresponding histology data and images
will be used to document reliably observable features in the confocal images that are
relevant to histopathology interpretation. Relevant images will be selected and discussed by
comparison to frozen or permanent section histology for compilation into an atlas
documenting comparison for the tumors seen in the study.