Evaluating the Effect of Broccoli Sprouts (Sulforaphane) on Cellular Proliferation, an Intermediate Marker of Breast Cancer Risk

Inclusion Criteria:

- Female 18 + years of age

- Confirmed diagnosis of DCIS on core or excisional/incisional biopsy and scheduled for
definitive surgery

- Pre or Post menopausal women reporting no use of hormone replacement therapy,
tamoxifen or raloxifene within the prior 6 months to eligibility screening

- Agree to avoid cruciferous vegetable/condiment intake for 14 days

- Agree to sign an informed consent and allow use of some tissue (slides) from biopsy
and definitive surgery for research purposes

Exclusion Criteria:

- Prior cancer diagnosis other than non-melanomatous skin cancer or cervical carcinoma
in-situ

- Used hormone replacement therapy, tamoxifen or raloxifene within the past 6 months
prior to eligibility screening

- Used antibiotics within 10 days prior to beginning cruciferous free diet (day -14
prior to surgery)

- Smoked within the past 12 months prior to eligibility screening;

- Active infection or inflammation of the breast at time of eligibility screening

- Has baseline comprehensive metabolic panel (CMP) [Glucose, Calcium, Albumin, Serum
total protein (TP), Sodium, Potassium, Carbon dioxide, Chloride, Blood urea nitrogen
(BUN), Creatinine, Alkaline phosphatase (ALP), Alanine amino transferase (AST),
Aspartate amino transferase (SGOT), and Bilirubin], prothrombin time (PT) and ,
complete blood count (CBC) values that are 1.5 times in either direction the reported
normal range