Inclusion Criteria:

- Age >/= 18 years.

- Histological or cytological documentation of non-hematologic, malignant solid tumor,
excluding primary brain or spinal tumors, or history of central nervous system
metastases

- At least one measurable lesion or evaluable disease

- Life expectancy of at least 12 weeks

- ECOG Performance Status of 0, 1 or 2

- PT-INR/PTT < 1.5 x upper limit of normal [Patients who are being therapeutically
anticoagulated with an agent such as coumadin or heparin will be allowed to
participate provided that no prior evidence of underlying abnormality in these
parameters exists]. Low-dose aspirin is permitted (
- Adequate bone marrow, liver and renal function

- Ability to understand and to sign an informed consent form; a signed informed
consent must be obtained prior to any study specific procedures

Exclusion Criteria:

- History of cardiac disease congestive heart failure (CHF) > NYHA Class II; active
coronary artery disease, myocardial infarction within 6 months prior to study entry;
new onset angina within 3 months prior to study entry or unstable angina or cardiac
arrhythmias requiring anti-arrhythmic therapy (beta-blockers or Digoxin are
permitted).

- Current diagnosis of type I or II diabetes mellitus or fasting blood glucose level
>125 mg/dL at screening, or HbA1c 7%

- Active clinically serious infections > Grade 2 (NCI-CTCAE Version 3.0)

- History of having received allogeneic organ transplant

- Uncontrolled seizure disorder. Use of cytochrome P450 enzyme-inducing antiepileptic
drugs (phenytoin, carbamazepine or phenobarbital) is not allowed throughout the
entire study.

- Uncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic
pressure > 90 mmHg, despite optimal medical management