DMS-0901: Multimodal Magnetic Resonance Protocol to Distinguish Tumor Recurrence From Treatment-Related Necrosis in Patients With High Grade Gliomas
N/A
18 Years
N/A
18 Years
N/A
Not Enrolling
Both
Recurrent High Grade Gliomas
Both
Recurrent High Grade Gliomas
Trial Information
DMS-0901: Multimodal Magnetic Resonance Protocol to Distinguish Tumor Recurrence From Treatment-Related Necrosis in Patients With High Grade Gliomas
Inclusion Criteria:
- Histologically proven high grae glioma with central pathology review at DHMC
- Age 18 equal to or greater than 18 years
- Karnofsky performance greater or equal to 60%
- Patients must have received radiation therapy and chemotherapy but should not have
received any anti-angiogenesis therapy.
Exclusion Criteria:
- Any patient who requires urgent surgical resection of MRI abnormality would not be
eligible
- Pregnant women are not eligible
Type of Study:
Observational
Study Design:
Time Perspective: Cross-Sectional
Outcome Measure:
To prospectively acquire multiparameter MR variables at 1.5T and 3T MRI from treated high grade glioma patients to assign tissue signatures for tumor recurrence and radiation necrosis as established by pathologic examination.
Outcome Time Frame:
24 months
Safety Issue:
No
Authority:
United States: Institutional Review Board
Study ID:
D0901
NCT ID:
NCT00942760
Start Date:
April 2009
Completion Date:
April 2011
Related Keywords:
- Recurrent High Grade Gliomas
- Glioma
- Necrosis
- Recurrence
Name | Location |
|---|---|
| Dartmouth-Hitchcock Medical Center | Lebanon, New Hampshire 03756 |
