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DMS-0901: Multimodal Magnetic Resonance Protocol to Distinguish Tumor Recurrence From Treatment-Related Necrosis in Patients With High Grade Gliomas


N/A
18 Years
N/A
Not Enrolling
Both
Recurrent High Grade Gliomas

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Trial Information

DMS-0901: Multimodal Magnetic Resonance Protocol to Distinguish Tumor Recurrence From Treatment-Related Necrosis in Patients With High Grade Gliomas


Inclusion Criteria:



- Histologically proven high grae glioma with central pathology review at DHMC

- Age 18 equal to or greater than 18 years

- Karnofsky performance greater or equal to 60%

- Patients must have received radiation therapy and chemotherapy but should not have
received any anti-angiogenesis therapy.

Exclusion Criteria:

- Any patient who requires urgent surgical resection of MRI abnormality would not be
eligible

- Pregnant women are not eligible

Type of Study:

Observational

Study Design:

Time Perspective: Cross-Sectional

Outcome Measure:

To prospectively acquire multiparameter MR variables at 1.5T and 3T MRI from treated high grade glioma patients to assign tissue signatures for tumor recurrence and radiation necrosis as established by pathologic examination.

Outcome Time Frame:

24 months

Safety Issue:

No

Authority:

United States: Institutional Review Board

Study ID:

D0901

NCT ID:

NCT00942760

Start Date:

April 2009

Completion Date:

April 2011

Related Keywords:

  • Recurrent High Grade Gliomas
  • Glioma
  • Necrosis
  • Recurrence

Name

Location
Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire  03756