A Randomized Phase III Trial of Cisplatin and Tumor Volume Directed Irradiation Followed by Carboplatin and Paclitaxel vs. Carboplatin and Paclitaxel for Optimally Debulked, Advanced Endometrial Carcinoma
Phase 3
18 Years
N/A
18 Years
N/A
Open (Enrolling)
Female
Endometrial Cancer
Female
Endometrial Cancer
Trial Information
A Randomized Phase III Trial of Cisplatin and Tumor Volume Directed Irradiation Followed by Carboplatin and Paclitaxel vs. Carboplatin and Paclitaxel for Optimally Debulked, Advanced Endometrial Carcinoma
OBJECTIVES:
Primary
- Compare the recurrence-free survival of patients with stage I-IVA endometrial carcinoma
treated with adjuvant chemoradiotherapy comprising cisplatin and tumor volume-directed
radiotherapy followed by carboplatin and paclitaxel vs carboplatin and paclitaxel
alone.
Secondary
- Compare the overall survival of patients treated with these regimens.
- Compare the acute and late adverse effects of these regimens in these patients.
- Determine the impact of these regimens on patient-reported quality of life during and
for up to 1 year after completion of study treatment.
OUTLINE: This is a multicenter study. Patients are randomized to 1 of 2 treatment arms.
- Arm I: Patients receive cisplatin IV on days 1 and 29. Patients also undergo
external-beam radiotherapy once daily, 5 days a week, for 5-6 weeks. Some patients may
then undergo brachytherapy over 2-3 weeks. Beginning within 8 weeks after completion of
chemoradiotherapy, patients receive paclitaxel IV over 3 hours and carboplatin IV on
day 1. Treatment repeats every 21 days for 4 courses in the absence of disease
progression or unacceptable toxicity.
- Arm II: Patients receive paclitaxel IV over 3 hours and carboplatin IV on day 1.
Treatment repeats every 21 days for 6 courses in the absence of disease progression or
unacceptable toxicity.
Patients complete quality-of-life questionnaires at baseline and periodically during study
using the FACT-G Physical and Functional Well-Being, FACT-Endometrial, FACT/GOG Neuropathy,
and FACT-C (items C3 and C5).
After completion of study therapy, patients are followed up every 3 months for 2 years,
every 6 months for 3 years, and then annually thereafter.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Histologically confirmed endometrial carcinoma, including the following cell types:
- Clear cell carcinoma
- Serous papillary carcinoma
- Undifferentiated carcinoma
- Surgical stage III or IVA disease per FIGO 2009 staging criteria
- Surgical stage III disease includes positive adnexa, tumor invading the serosa,
positive pelvic and/or para-aortic nodes, or vaginal involvement
- Surgical stage IVA disease includes bladder or bowel mucosal involvement, but no
spread outside the pelvis
- Surgical stage I or II endometrial clear cell or serous papillary carcinoma with
positive peritoneal cytology per FIGO 2009 staging criteria
- Has undergone optimal surgical debulking that included a hysterectomy and bilateral
salpingo-oophorectomy within the past 8 weeks
- Residual tumor after surgery (any single site) ≤ 2 cm in maximum dimension
- No carcinosarcoma
- No parenchymal liver metastases
- No recurrent endometrial cancer or endometrioid stage I or II with positive
peritoneal cytology
PATIENT CHARACTERISTICS:
- GOG performance status 0-2
- Life expectancy ≥ 3 months
- WBC ≥ 3,000/mm^3
- ANC ≥ 1,500/mm^3
- Platelet count ≥ 100,000/mm^3
- SGOT and SGPT ≤ 2.5 times upper limit of normal (ULN)
- Alkaline phosphatase ≤ 2.5 times ULN
- Bilirubin ≤ 1.5 times ULN
- Creatinine ≤ ULN
- No myocardial infarction, unstable angina, or uncontrolled arrhythmia within the past
3 months
- No other active invasive malignancy within the past 5 years except for non-melanoma
skin cancer
- No history of serious co-morbid or uncontrolled illness that would preclude study
therapy
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- No prior pelvic or abdominal radiotherapy
- No prior chemotherapy for endometrial cancer
- No prior cancer treatment that would preclude study therapy
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Masking: Open Label, Primary Purpose: Treatment
Outcome Measure:
Recurrence-free survival
Safety Issue:
No
Principal Investigator
Daniela E. Matei, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Indiana University Melvin and Bren Simon Cancer Center
Authority:
Unspecified
Study ID:
CDR0000649079
NCT ID:
NCT00942357
Start Date:
June 2009
Completion Date:
Related Keywords:
- Endometrial Cancer
- endometrial clear cell carcinoma
- endometrial papillary serous carcinoma
- stage IA endometrial carcinoma
- stage IB endometrial carcinoma
- stage II endometrial carcinoma
- stage IIIA endometrial carcinoma
- stage IIIB endometrial carcinoma
- stage IIIC endometrial carcinoma
- stage IVA endometrial carcinoma
- stage IVB endometrial carcinoma
- Endometrial Neoplasms
- Sarcoma, Endometrial Stromal
- Adenoma
Name | Location |
|---|---|
| National Naval Medical Center | Bethesda, Maryland 20889 |
| Fred Hutchinson Cancer Research Center | Seattle, Washington 98109 |
| Memorial Sloan-Kettering Cancer Center | New York, New York 10021 |
| Mayo Clinic Scottsdale | Scottsdale, Arizona 85259 |
| Mayo Clinic - Jacksonville | Jacksonville, Florida 32224 |
| Mayo Clinic Cancer Center | Rochester, Minnesota 55905 |
| MBCCOP - Hawaii | Honolulu, Hawaii 96813 |
| University of Chicago Cancer Research Center | Chicago, Illinois 60637 |
| Barbara Ann Karmanos Cancer Institute | Detroit, Michigan 48201 |
| Tripler Army Medical Center | Honolulu, Hawaii 96859-5000 |
| CCOP - Wichita | Wichita, Kansas 67214-3882 |
| CCOP - Christiana Care Health Services | Wilmington, Delaware 19899 |
| CCOP - Illinois Oncology Research Association | Peoria, Illinois 61602 |
| CCOP - Iowa Oncology Research Association | Des Moines, Iowa 50309-1016 |
| CCOP - Metro-Minnesota | Saint Louis Park, Minnesota 55416 |
| George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus | New Britain, Connecticut 06050 |
| Mercy Medical Center - Sioux City | Sioux City, Iowa 51104 |
| Siouxland Hematology-Oncology Associates, LLP | Sioux City, Iowa 51101 |
| St. Luke's Regional Medical Center | Sioux City, Iowa 51104 |
| Baystate Regional Cancer Program at D'Amour Center for Cancer Care | Springfield, Massachusetts 01199 |
| Bronson Methodist Hospital | Kalamazoo, Michigan 49007 |
| West Michigan Cancer Center | Kalamazoo, Michigan 49007-3731 |
| Borgess Medical Center | Kalamazooaa, Michigan 49001 |
| Fairview Ridges Hospital | Burnsville, Minnesota 55337 |
| Mercy and Unity Cancer Center at Mercy Hospital | Coon Rapids, Minnesota 55433 |
| Fairview Southdale Hospital | Edina, Minnesota 55435 |
| Mercy and Unity Cancer Center at Unity Hospital | Fridley, Minnesota 55432 |
| Hutchinson Area Health Care | Hutchinson, Minnesota 55350 |
| HealthEast Cancer Care at St. John's Hospital | Maplewood, Minnesota 55109 |
| Hennepin County Medical Center - Minneapolis | Minneapolis, Minnesota 55415 |
| Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | Minneapolis, Minnesota 55407 |
| St. Francis Cancer Center at St. Francis Medical Center | Shakopee, Minnesota 55379 |
| Park Nicollet Cancer Center | St. Louis Park, Minnesota 55416 |
| Regions Hospital Cancer Care Center | St. Paul, Minnesota 55101 |
| United Hospital | St. Paul, Minnesota 55102 |
| Ridgeview Medical Center | Waconia, Minnesota 55387 |
| Aultman Cancer Center at Aultman Hospital | Canton, Ohio 44710-1799 |
| Case Comprehensive Cancer Center | Cleveland, Ohio 44106-5065 |
| MetroHealth Cancer Care Center at MetroHealth Medical Center | Cleveland, Ohio 44109 |
| Abramson Cancer Center of the University of Pennsylvania | Philadelphia, Pennsylvania 19104-4283 |
| Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center | Wilkes-Barre, Pennsylvania 18711 |
| Sanford Cancer Center at Sanford USD Medical Center | Sioux Falls, South Dakota 57117-5039 |
| Avera Cancer Institute | Sioux Falls, South Dakota 57105 |
| University of Wisconsin Paul P. Carbone Comprehensive Cancer Center | Madison, Wisconsin 53792-6164 |
| Marshfield Clinic - Marshfield Center | Marshfield, Wisconsin 54449 |
| Medical College of Wisconsin Cancer Center | Milwaukee, Wisconsin 53226 |
| St. Joseph's Hospital and Medical Center | Phoenix, Arizona 85001-2071 |
| Memorial Hospital of South Bend | South Bend, Indiana 46601 |
| CCOP - Cancer Research for the Ozarks | Springfield, Missouri 65807 |
| CCOP - Montana Cancer Consortium | Billings, Montana 59101 |
| CCOP - Columbus | Columbus, Ohio 43206 |
| CCOP - Greenville | Greenville, South Carolina 29615 |
| University of Texas Medical Branch | Galveston, Texas 77555-1329 |
| LDS Hospital | Salt Lake City, Utah 84143 |
| Rush University Medical Center | Chicago, Illinois 60612-3824 |
| CCOP - Northern Indiana CR Consortium | South Bend, Indiana 46601 |
| Saint Joseph Regional Medical Center | South Bend, Indiana 46617 |
| Holden Comprehensive Cancer Center at University of Iowa | Iowa City, Iowa 52242-1002 |
| UMASS Memorial Cancer Center - University Campus | Worcester, Massachusetts 01605-2982 |
| Ellis Fischel Cancer Center at University of Missouri - Columbia | Columbia, Missouri 65203 |
| Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | Lebanon, New Hampshire 03756-0002 |
| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Chapel Hill, North Carolina 27599-7570 |
| Charles M. Barrett Cancer Center at University Hospital | Cincinnati, Ohio 45267-0526 |
| Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia, Pennsylvania 19107 |
| UPMC Cancer Center at Magee-Womens Hospital | Pittsburgh, Pennsylvania 15213-3180 |
| MultiCare Regional Cancer Center at Tacoma General Hospital | Tacoma, Washington 98405 |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore, Maryland 21231-2410 |
| Cancer Research Center of Hawaii | Honolulu, Hawaii 96813 |
| Utah Valley Regional Medical Center - Provo | Provo, Utah 84604 |
| Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center | Milwaukee, Wisconsin 53201-2901 |
| University of California Davis Cancer Center | Sacramento, California 95817 |
| Wesley Medical Center | Wichita, Kansas 67214 |
| Fletcher Allen Health Care - University Health Center Campus | Burlington, Vermont 05401 |
| John Stoddard Cancer Center at Iowa Methodist Medical Center | Des Moines, Iowa 50309 |
| Kaiser Permanente Medical Center - San Francisco Geary Campus | San Francisco, California 94115 |
| Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center | Kansas City, Kansas 66160-7353 |
| Josephine Ford Cancer Center at Henry Ford Hospital | Detroit, Michigan 48202 |
| Swedish Cancer Institute at Swedish Medical Center - First Hill Campus | Seattle, Washington 98104 |
| James Graham Brown Cancer Center at University of Louisville | Louisville, Kentucky 40202 |
| Blumenthal Cancer Center at Carolinas Medical Center | Charlotte, North Carolina 28232-2861 |
| Overlook Hospital | Summit, New Jersey 07902-0220 |
| Northside Hospital Cancer Center | Atlanta, Georgia 30342-1611 |
| Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center | Baltimore, Maryland 21237 |
| Hulston Cancer Center at Cox Medical Center South | Springfield, Missouri 65807 |
| St. John's Regional Health Center | Springfield, Missouri 65804 |
| Carol G. Simon Cancer Center at Morristown Memorial Hospital | Morristown, New Jersey 07962 |
| SUNY Downstate Medical Center | Brooklyn, New York 11203 |
| Winthrop University Hospital | Mineola, New York 11501 |
| Lake/University Ireland Cancer Center | Mentor, Ohio 44060 |
| Women and Infants Hospital of Rhode Island | Providence, Rhode Island 02905 |
| Carilion Gynecologic Oncology Associates | Roanoke, Virginia 24014 |
| Long Island Jewish Medical Center | New Hyde Park, New York 11040 |
| Kaiser Permanente Medical Center - Oakland | Sacramento, California 95825 |
| Yale Cancer Center | New Haven, Connecticut 06520-8028 |
| Florida Hospital Cancer Institute at Florida Hospital Orlando | Orlando, Florida 32803-1273 |
| Advocate Christ Medical Center | Oak Lawn, Illinois 60453 |
| Via Christi Cancer Center at Via Christi Regional Medical Center | Wichita, Kansas 67214 |
| Ochsner Cancer Institute at Ochsner Clinic Foundation | New Orleans, Louisiana 70121 |
| Alvin and Lois Lapidus Cancer Institute at Sinai Hospital | Baltimore, Maryland 21215 |
| NYU Cancer Institute at New York University Medical Center | New York, New York 10016 |
| Mount Sinai Medical Center | New York, New York 10029 |
| Stony Brook University Cancer Center | Stony Brook, New York 11794-8174 |
| SUNY Upstate Medical University Hospital | Syracuse, New York 13210 |
| Wake Forest University Comprehensive Cancer Center | Winston-Salem, North Carolina 27157-1096 |
| Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas | Dallas, Texas 75390 |
| St. Vincent Hospital Regional Cancer Center | Green Bay, Wisconsin 54307-3508 |
| Green Bay Oncology, Limited - Escanaba | Escanaba, Michigan 49431 |
| Dickinson County Healthcare System | Iron Mountain, Michigan 49801 |
| St. Mary's Hospital Medical Center - Green Bay | Green Bay, Wisconsin 54303 |
| Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center | Green Bay, Wisconsin 54301-3526 |
| Green Bay Oncology, Limited at St. Mary's Hospital | Green Bay, Wisconsin 54303 |
| Green Bay Oncology, Limited - Oconto Falls | Oconto Falls, Wisconsin 54154 |
| Green Bay Oncology, Limited - Sturgeon Bay | Sturgeon Bay, Wisconsin 54235 |
| Sibley Memorial Hospital | Washington, District of Columbia 20016 |
| Wayne Memorial Hospital, Incorporated | Goldsboro, North Carolina 27534 |
| Adena Regional Medical Center | Chillicothe, Ohio 54601 |
| Doctors Hospital at Ohio Health | Columbus, Ohio 43228 |
| Riverside Methodist Hospital Cancer Care | Columbus, Ohio 43214 |
| Grady Memorial Hospital | Delaware, Ohio 43015 |
| Strecker Cancer Center at Marietta Memorial Hospital | Marietta, Ohio 45750 |
| Licking Memorial Cancer Care Program at Licking Memorial Hospital | Newark, Ohio 43055 |
| Community Hospital of Springfield and Clark County | Springfield, Ohio 45505 |
| Genesis - Good Samaritan Hospital | Zanesville, Ohio 43701 |
| Utah Cancer Specialists at UCS Cancer Center | Salt Lake City, Utah 84106 |
| Olympic Hematology and Oncology | Bremerton, Washington 98310 |
| Skagit Valley Hospital Cancer Care Center | Mt. Vernon, Washington 98273 |
| University Cancer Center at University of Washington Medical Center | Seattle, Washington 98195 |
| Group Health Central Hospital | Seattle, Washington 98104 |
| University of South Alabama Mitchell Cancer Institute | Mobile, Alabama 36604 |
| UCSF Helen Diller Family Comprehensive Cancer Center | San Francisco, California 94115 |
| Kaiser Permanente Medical Center - Santa Clara Kiely Campus | Santa Clara, California 95051-5386 |
| M.D. Anderson Cancer Center at Orlando | Orlando, Florida 32806 |
| Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center | Savannah, Georgia 31403-3089 |
| Advocate Lutheran General Cancer Care Center | Park Ridge, Illinois 60068-1174 |
| Swedish-American Regional Cancer Center | Rockford, Illinois 61104-2315 |
| Indiana University Melvin and Bren Simon Cancer Center | Indianapolis, Indiana 46202-5289 |
| Lucille P. Markey Cancer Center at University of Kentucky | Lexington, Kentucky 40536-0093 |
| Tulane Cancer Center Office of Clinical Research | Alexandria, Louisiana 71315-3198 |
| CancerCare of Maine at Eastern Maine Medical Center | Bangor, Maine 04401 |
| University of Mississippi Cancer Clinic | Jackson, Mississippi 39216-4505 |
| Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | St. Louis, Missouri 63110 |
| CCOP - Nevada Cancer Research Foundation | Las Vegas, Nevada 89109-2306 |
| University of New Mexico Cancer Center | Albuquerque, New Mexico 87131-5636 |
| Don Monti Comprehensive Cancer Center at North Shore University Hospital | Manhasset, New York 11030 |
| Beth Israel Medical Center - Petrie Division | New York, New York 10003-3803 |
| St. Luke's - Roosevelt Hospital Center - St.Luke's Division | New York, New York 10027 |
| Oklahoma University Cancer Institute | Oklahoma City, Oklahoma 73104 |
| Knight Cancer Institute at Oregon Health and Science University | Portland, Oregon 97239-3098 |
| Geisinger Cancer Institute at Geisinger Health | Danville, Pennsylvania 17822-0001 |
| Gundersen Lutheran Center for Cancer and Blood | La Crosse, Wisconsin 54601 |
| Kaiser Permanente Medical Center - Sacramento | Sacramento, California 95825 |
| Methodist Estabrook Cancer Center | Omaha, Nebraska 68114-4199 |
| Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center | Orange, California 92868 |
| Huntsman Cancer Institute at University of Utah | Salt Lake City, Utah 84112 |
| University of Virginia Cancer Center | Charlottesville, Virginia 22908 |
| Robert H. Lurie Comprehensive Cancer Center at Northwestern University | Chicago, Illinois 60611 |
| Todd Cancer Institute at Long Beach Memorial Medical Center | Long Beach, California 90801 |
| Elkhart General Hospital | Elkhart, Indiana 46515 |
| Howard Community Hospital | Kokomo, Indiana 46904 |
| Maine Medical Center - Bramhall Campus | Portland, Maine 04102 |
| Lakeland Regional Cancer Care Center - St. Joseph | St. Joseph, Michigan 49085 |
| Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton | Marlton, New Jersey 08053 |
| Fox Chase Virtua Health Cancer Program at Virtua West Jersey | Voorhees, New Jersey 08043 |
| Hope A Women's Cancer Center | Asheville, North Carolina 28801 |
| Mount Carmel Health - West Hospital | Columbus, Ohio 43222 |
| Cancer Care Associates - Saint Francis Campus | Tulsa, Oklahoma 74136-1929 |
| Rosenfeld Cancer Center at Abington Memorial Hospital | Abington, Pennsylvania 19001 |
| Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest | Allentown, Pennsylvania 18105 |
| Fox Chase Cancer Center - Philadelphia | Philadelphia, Pennsylvania 19111-2497 |
| Front Range Cancer Specialists | Fort Collins, Colorado 80528 |
| All Saints Cancer Center at Wheaton Franciscan Healthcare | Racine, Wisconsin 53405 |
| Kaiser Permanente Medical Center - Hayward | Hayward, California 94545 |
| Kaiser Permanente Medical Center - Redwood City | Redwood City, California 94063 |
| Kaiser Permanente Medical Center - Richmond | Richmond, California 94801 |
| Kaiser Permanente Medical Center - Roseville | Roseville, California 95661 |
| South Sacramento Kaiser-Permanente Medical Center | Sacramento, California 95823 |
| Kaiser Permanente Medical Center - Santa Teresa | San Jose, California 95119 |
| Kaiser Foundation Hospital - San Rafael | San Rafael, California 94903 |
| Kaiser Permanente Medical Center - Santa Rosa | Santa Rosa, California 95403 |
| Kaiser Permanente Medical Center - South San Francisco | South San Francisco, California 94080 |
| Kaiser Permanente Medical Facility - Stockton | Stockton, California 95210 |
| Kaiser Permanente Medical Center - Walnut Creek | Walnut Creek, California 94596 |
| John Muir/Mt. Diablo Comprehensive Cancer Center | Walnut Creek, California 94598 |
| Poudre Valley Hospital | Fort Collins, Colorado 80524 |
| St. Joseph Medical Center | Bloomington, Illinois 61701 |
| BroMenn Regional Medical Center | Normal, Illinois 61761 |
| Community Cancer Center | Normal, Illinois 61761 |
| Community Hospital of Ottawa | Ottawa, Illinois 61350 |
| Oncology Hematology Associates of Central Illinois, PC - Ottawa | Ottawa, Illinois 61350 |
| Oncology Hematology Associates of Central Illinois, PC - Peoria | Peoria, Illinois 61615 |
| OSF St. Francis Medical Center | Peoria, Illinois 61637 |
| Valley Cancer Center | Spring Valley, Illinois 61362 |
| Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte, Indiana 46350 |
| John Stoddard Cancer Center at Iowa Lutheran Hospital | Des Moines, Iowa 50316-2301 |
| Medical Oncology and Hematology Associates at John Stoddard Cancer Center | Des Moines, Iowa 50309 |
| Medical Oncology and Hematology Associates at Mercy Cancer Center | Des Moines, Iowa 50314 |
| Mercy Cancer Center at Mercy Medical Center - Des Moines | Des Moines, Iowa 50314 |
| Medical Oncology and Hematology Associates - West Des Moines | West Des Moines, Iowa 50266 |
| Cancer Center of Kansas, PA - Dodge City | Dodge City, Kansas 67801 |
| Sturdy Memorial Hospital | Attleboro, Massachusetts 02703 |
| Cancer Institute of New Jersey at Cooper - Voorhees | Voorhees, New Jersey 08043 |
| David L. Rike Cancer Center at Miami Valley Hospital | Dayton, Ohio 45409 |
| Charles F. Kettering Memorial Hospital | Kettering, Ohio 45429 |
| Dixie Regional Medical Center - East Campus | Saint George, Utah 84770 |
| Palo Alto Medical Foundation | Palo Alto, California 94301 |
| Randolph Hospital | Asheboro, North Carolina 27203 |
| Moses Cone Regional Cancer Center at Wesley Long Community Hospital | Greensboro, North Carolina 27401 |
| Annie Penn Cancer Center | Reidsville, North Carolina 27320 |
| Altru Cancer Center at Altru Hospital | Grand Forks, North Dakota 58201 |
| Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital | Pittsburgh, Pennsylvania 15224-1791 |
| UAB Comprehensive Cancer Center | Birmingham, Alabama 35294 |
| Stanford Cancer Center | Stanford, California 94305-5824 |
| Eastern Connecticut Hematology and Oncology Associates | Norwich, Connecticut 06360 |
| Tunnell Cancer Center at Beebe Medical Center | Lewes, Delaware 19958 |
| John B. Amos Cancer Center | Columbus, Georgia 31904 |
| Evanston Hospital | Evanston, Illinois 60201-1781 |
| Michiana Hematology-Oncology, PC - Elkhart | Elkhart, Indiana 46514 |
| Elkhart Clinic, LLC | Elkhart, Indiana 46514-2098 |
| Michiana Hematology Oncology PC - La Porte | La Porte, Indiana 46350 |
| Michiana Hematology-Oncology, PC - South Bend | Mishawaka, Indiana 46545-1470 |
| Michiana Hematology Oncology PC - Plymouth | Plymouth, Indiana 46563 |
| McFarland Clinic, PC | Ames, Iowa 50010 |
| Cancer Center of Kansas, PA - Chanute | Chanute, Kansas 66720 |
| Cancer Center of Kansas, PA - El Dorado | El Dorado, Kansas 67042 |
| Cancer Center of Kansas - Fort Scott | Fort Scott, Kansas 66701 |
| Cancer Center of Kansas-Independence | Independence, Kansas 67301 |
| Cancer Center of Kansas, PA - Kingman | Kingman, Kansas 67068 |
| Lawrence Memorial Hospital | Lawrence, Kansas 66044 |
| Cancer Center of Kansas, PA - Liberal | Liberal, Kansas 67905 |
| Cancer Center of Kansas, PA - Newton | Newton, Kansas 67114 |
| Saint Luke's Hospital - South | Overland Park, Kansas 66213 |
| Cancer Center of Kansas, PA - Parsons | Parsons, Kansas 67357 |
| Cancer Center of Kansas, PA - Pratt | Pratt, Kansas 67124 |
| Cancer Center of Kansas, PA - Salina | Salina, Kansas 67401 |
| Cancer Center of Kansas, PA - Wellington | Wellington, Kansas 67152 |
| Cancer Center of Kansas, PA - Wichita | Wichita, Kansas 67214 |
| Associates in Womens Health, PA - North Review | Wichita, Kansas 67208 |
| Cancer Center of Kansas, PA - Medical Arts Tower | Wichita, Kansas 67208 |
| Cancer Center of Kansas, PA - Winfield | Winfield, Kansas 67156 |
| Greater Baltimore Medical Center Cancer Center | Baltimore, Maryland 21204 |
| Michiana Hematology Oncology PC - Niles | Niles, Michigan 49120 |
| Lakeside Cancer Specialists, PLLC | Saint Joseph, Michigan 49085 |
| Willmar Cancer Center at Rice Memorial Hospital | Willmar, Minnesota 56201 |
| Saint Luke's Cancer Institute at Saint Luke's Hospital | Kansas City, Missouri 64111 |
| Research Medical Center | Kansas City, Missouri 64132 |
| Saint Luke's East - Lee's Summit | Lee's Summit, Missouri 64086 |
| Heartland Regional Medical Center | Saint Joseph, Missouri 64506 |
| Saint Joseph Oncology, Incorporated | Saint Joseph, Missouri 64507 |
| Billings Clinic - Downtown | Billings, Montana 59107-7000 |
| Great Falls Clinic - Main Facility | Great Falls, Montana 59405 |
| Sletten Cancer Institute at Benefis Healthcare | Great Falls, Montana 59405 |
| Monter Cancer Center of the North Shore-LIJ Health System | Lake Success, New York 11042 |
| Summa Center for Cancer Care at Akron City Hospital | Akron, Ohio 44309-2090 |
| Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center | Columbus, Ohio 43210-1240 |
| Grant Medical Center Cancer Care | Columbus, Ohio 43215 |
| Mount Carmel St. Ann's Cancer Center | Westerville, Ohio 43081 |
| St. Luke's Cancer Network at St. Luke's Hospital | Bethlehem, Pennsylvania 18015 |
| Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center | Hershey, Pennsylvania 17033-0850 |
| McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center | Reading, Pennsylvania 19612-6052 |
| Sandra L. Maxwell Cancer Center | Cedar City, Utah 84720 |
| Jon and Karen Huntsman Cancer Center at Intermountain Medical Center | Murray, Utah 84157 |
| Val and Ann Browning Cancer Center at McKay-Dee Hospital Center | Ogden, Utah 84403 |
| Harrison Poulsbo Hematology and Onocology | Poulsbo, Washington 98370 |
| Franciscan Cancer Center at St. Joseph Medical Center | Tacoma, Washington 98405-3004 |
| Wenatchee Valley Medical Center | Wenatchee, Washington 98801-2028 |
| Center for Cancer Treatment & Prevention at Sacred Heart Hospital | Eau Claire, Wisconsin 54701 |
| Marshfield Clinic Cancer Care at Regional Cancer Center | Eau Claire, Wisconsin 54701 |
| Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center | Green Bay, Wisconsin 54311 |
| Saint Joseph's Hospital | Marshfield, Wisconsin 54449 |
| Marshfield Clinic - Lakeland Center | Minocqua, Wisconsin 54548 |
| Ministry Medical Group at Saint Mary's Hospital | Rhinelander, Wisconsin 54501 |
| Marshfield Clinic at Saint Michael's Hospital | Stevens Point, Wisconsin 54481 |
| Saint Michael's Hospital Cancer Center | Stevens Point, Wisconsin 54481 |
| Aurora Medical Center | Summit, Wisconsin 53066 |
| Vince Lombardi Cancer Clinic - Two Rivers | Two Rivers, Wisconsin 54241 |
| Marshfield Clinic - Weston Center | Weston, Wisconsin 54476 |
| Diagnostic and Treatment Center | Weston, Wisconsin 54476 |
| Woman's Hospital | Baton Rouge, Louisiana 70815 |
| Fox Chase Cancer Center CCOP Research Base | Philadelphia, Pennsylvania 19140 |
| Seattle Cancer Care Alliance | Seattle, Washington 98109 |
| Regional Cancer Center at Memorial Medical Center | Springfield, Illinois 62781-0001 |
| John H. Stroger, Jr. Hospital of Cook County | Chicago, Illinois 60612-9985 |
| Community Hospital | Munster, Indiana 46321 |
| Methodist Hospital | Houston, Texas 77030 |
| Aurora Sinai Medical Center | Milwaukee, Wisconsin 53201-0342 |
| St. Joseph Hospital Regional Cancer Center - Orange | Orange, California 92868-3849 |
| St. Vincent's Medical Center | Bridgeport, Connecticut 06606 |
| Queen's Cancer Institute at Queen's Medical Center | Honolulu, Hawaii 96813 |
| Union Hospital of Cecil County | Elkton MD, Maryland 21921 |
| Duke Cancer Institute | Durham, North Carolina 27710 |
| Cancer Centers of the Carolinas - Faris Road | Greenville, South Carolina 29605 |
| Cancer Centers of the Carolinas - Seneca | Seneca, South Carolina 29672 |
| Cancer Centers of the Carolinas - Spartanburg | Spartanburg, South Carolina 29307 |
| Pacific Gynecology Specialists | Seattle, Washington 98104 |
| Crozer-Chester Medical Center | Upland, Pennsylvania 19013 |
| Cancer Centers of the Carolinas - Eastside | Greenville, South Carolina 29601 |
| Rockwood Clinic Cancer Treatment Center | Spokane, Washington 99204-2967 |
| University of Wisconcin Cancer Center at Aspirus Wausau Hospital | Wausau, Wisconsin 54401 |
| Gynecologic Oncology | Hinsdale, Illinois 60521 |
| Louisville Oncology at Norton Cancer Institute - Louisville | Louisville, Kentucky 40202 |
| Women's Cancer Center - La Canada | Las Vegas, Nevada 89169 |
| Kapiolani Medical Center at Pali Momi | Aiea, Hawaii 96701 |
| Straub Clinic and Hospital, Incorporated | Honolulu, Hawaii 96813 |
| Hawaii Medical Center - East | Honolulu, Hawaii 96817 |
| Maui Memorial Medical Center | Wailuku, Hawaii 96793 |
| Valley Hospital - Ridgewood | Ridgewood, New Jersey 07450 |
| Fountain Valley, California 92708 | |
| Olive View - UCLA Medical Center Foundation | Sylmar, California 91342 |
| University of Colorado Cancer Center at UC Health Sciences Center | Aurora, Colorado 80045 |
| Jersey Shore Cancer Center at Jersey Shore University Medical Center | Neptune, New Jersey 07754-0397 |
| Alamance Cancer Center at Alamance Regional Medical Center | Burlington, North Carolina 27216 |
| Northwest Hospital and Medical Center | Seattle, Washington 98133 |
| Cancer Care Center at John Muir Health - Concord Campus | Concord, California 94524-4110 |
| Cancer Centers of the Carolinas - Greer Radiation Oncology | Greer, South Carolina 29650 |
| Minnesota Oncology - Maplewood | Maplewood, Minnesota 55109 |
| Humphrey Cancer Center at North Memorial Outpatient Center | Robbinsdale, Minnesota 55422-2900 |
| Lakeview Hospital | Stillwater, Minnesota 55082 |
| Minnesota Oncology - Woodbury | Woodbury, Minnesota 55125 |
| Central Georgia Gynecologic Oncology | Macon, Georgia 31201 |
| St. Mary Regional Cancer Center at St. Mary Medical Center | Walla Walla, Washington 99362 |
| Harrison Medical Center | Bremerton, Washington 98310 |
| Kaiser Permanente - Division of Research - Oakland | Oakland, California 94611 |
| Rohnert Park Cancer Center | Rohnert Park, California 94928 |
| CCOP - Kansas City | Prairie Village, Kansas 66208 |
| St. Agnes Hospital Cancer Center | Baltimore, Maryland 21229 |
| Renown Institute for Cancer at Renown Regional Medical Center | Reno, Nevada 89502 |
| Gynecologic Oncology of West Michigan | Grand Rapids, Michigan 49546 |
| Southwest Gynecologic Oncology Associates, Incorporated | Albuquerque, New Mexico 87102 |
| Women's Cancer Care Associates | Albany, New York 12208 |
| Schwartz Gynecologic Oncology | Brightwaters, New York 11718 |
| Black Hills Obstetrics & Gynecology LLP | Rapid City, South Dakota 57701 |
| Aurora Women's Pavilion of West Allis Memorial Hospital | West Allis, Wisconsin 53227 |
| Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh, Wisconsin 54904 |
| Tufts Medical Center Cancer Center | Boston, Massachusetts 02111 |
| Central Dupage Cancer Center | Warrenville, Illinois 60555 |
| University of New Mexico Cancer Center - South | Las Cruces, New Mexico 88011 |
| New Ulm Medical Center | New Ulm, Minnesota 56073 |
| Southern Ohio Medical Center Cancer Center | Portsmouth, Ohio 45662 |
| Norton Suburban Hospital | Louisville, Kentucky 40207 |
| Providence Regional Cancer Partnership | Everett, Washington 98201 |
| St. Vincent Oncology Center | Indianapolis, Indiana 46260 |
| Zangmeister Center | Columbus, Ohio 43219 |
| Leonard Lawson Cancer Center at Pikeville Medical Center | Pikeville, Kentucky 41501 |
| Women's Institute for Gynecologic Cancer and Special Pelvic Surgery | Phillipsburg, New Jersey 08865 |
| PeaceHealth Medical Group, PC at St. Joseph Hospital | Bellingham, Washington 98226 |
| Olympic Medical Cancer Center | Sequim, Washington 98382 |
