A Multi-center, Randomized, Double-blind, Placebo-controlled Clinical Trial of Deferasirox in Patients With Myelodysplastic Syndromes (Low/Int-1 Risk) and Transfusional Iron Overload
Interventional
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
To compare deferasirox to placebo with regard to event-free survival (a composite primary endpoint including death and non-fatal events related to cardiac and liver function) in low and int-1 risk MDS patient with transfusional iron overload.
1 year - 5 years
No
Novartis Pharmaceuticals
Study Director
Novartis Pharmaceuticals
United States: Food and Drug Administration
CICL670A2302
NCT00940602
March 2010
January 2018
Name | Location |
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Hendrick Cancer Center | Abilene, Texas 79601-2316 |
Texas Cancer Center - Abilene | Abilene, Texas 79606 |
Puget Sound Cancer Center | Edmonds, Washington 98026 |
University of Chicago Medical Center Dept. of U. of Chicago Hosp(3) | Chicago, Illinois 60546 |
Hematology/Oncology Consultants Inc. | West Worthington, Ohio 43235 |
US Oncology Central Monitoring | Dallas, Texas 75246 |
Cancer Care Centers of South Texas / HOAST CCC of So. TX- San Antonio | San Antonio, Texas 78229 |
Rocky Mountain Cancer Centers RMCC - Denver-Midtown | Greenwood Village, Colorado |
Tyler Cancer Center Dept.ofTylerCancerCtr. | Tyler, Texas 75702 |
Dean Health System | Madison, Wisconsin 53717 |
Arizona Oncology Associates Phoenix | Phoenix, Arizona |
Hematology Oncology Services of Arkansas HOSA 2 | Little Rock, Arkansas 72205 |
Pacific Cancer Medical Center, Inc. PAC Center | Anaheim, California 92801 |
Tower Cancer Research Tower Oncology | Beverly Hills, California 90211 |
City of Hope National Medical Center City of Hope Medical Center | Duarte, California 91010 |
Long Beach VA Medical Center Dept. of Long Beach VA Med.Ctr | Long Beach, California 90822 |
USC/Kenneth Norris Comprehensive Cancer Center USC | Los Angeles, California 90033 |
Comprehensive Cancer Center CCC - Palm Spriings | Palm Springs, California 92262 |
Hartford Hospital Cancer Clinic Office | Hartford, Connecticut 06102 |
Sylvester Comprehensive Cancer Center Sylvester Cancer | Miami, Florida 33136 |
Florida Medical Clinic PA Dept.ofFloridaMedicalClinic | Zephyrhills, Florida 33542 |
Northeast Georgia Cancer Care Dept of NE Georgia Cancer (2) | Athens, Georgia 30607 |
Mountain States Tumor Institute Mountain States | Boise, Idaho 83712 |
Rush University Medical Center Div.ofHematology&Oncology (2) | Chicago, Illinois 60612 |
North Shore University Health System NSU | Evanston, Illinois 60201 |
North Shore University Health System North Shore | Evanston, Illinois 60201 |
University of Iowa Hospitals & Clinics Univ Iowa | Iowa City, Iowa 52242 |
Siouxland Hematology-Oncology Associates LLP SHO | Sioux City, Iowa 51101 |
LSU HEALTH SCIENCES CENTER/ LSU SCHOOL OF MEDICINE Feist-Weiller Cancer Center(3) | New Orleans, Louisiana 70115 |
Henry Ford Hospital Henry Ford | Detroit, Michigan 48202 |
Essentia Health Duluth Clinic Duluth Clinic | Duluth, Minnesota 55805 |
Veterans Medical Center -Minneapolis MVMC | Minneapolis, Minnesota 55417 |
Missouri Cancer Associates Dept.ofMissouriCancerAssoc. | Columbia, Missouri 65201 |
Midwest Cancer Care Physicians MMCC | Kansas City, Missouri 64131 |
Washington University School Of Medicine-Siteman Cancer Ctr WUSCM | St. Louis, Missouri 63110 |
VA Southern Nevada Healthcare System VASNHS | Las Vegas, Nevada 89106 |
Comprehensive Cancer Centers of Nevada CCC Nevada US Onc | Las Vegas, Nevada 89109 |
Southern Nevada Cancer Research Foundation Dept.of So. NV CancerRes.Fdn | Las Vegas, Nevada 89106 |
East Orange VA Medical Center Dept.ofHematology/Oncology(2) | East Orange, New Jersey 07018-1095 |
Hackensack University Medical Center Dept.of HackensackUniv.MedCtr. | Hackensack, New Jersey 07601 |
Hematology Oncology Associates of Northern New Jersey PA DeptofHem-OncofNorthern NJ (3) | Morristown, New Jersey 07962 |
UMDNJ-Robert Wood Johnson Clinical Research Center UMDNJ-Robert Wood Johnson Med | New Brunswick, New Jersey 08903 |
Overlook Hospital - Carol G Simon Cancer Center Carol G Simon | Summit, New Jersey 07901 |
Montefiore Medical Center Medical Oncology | Bronx, New York 10467 |
St. Vincent's Comprehensive Cancer Center St Vincents CCC | New York, New York 10011 |
New York Oncology Hematology, P.C. Dept. of New York Oncology. PC | Troy, New York 12180 |
Wake Forest University Baptist Medical Center Dept. of WFUHS (2) | Winston-Salem, North Carolina 27157 |
University of Oklahoma Health Sciences Center Univ OK HSC | Oklahoma City, Oklahoma 73104 |
Western Pennsylvania Hospital The Western Pennsylvania Hospi | Pittsburgh, Pennsylvania 15224 |
The West Clinic Dept. of the West Clinic | Memphis, Tennessee 38120 |
Cancer Center of the High Plains | Amarillo, Texas 79106 |
South Texas Institute of Cancer South Texas | Corpus Christi, Texas 78405 |
Texas Oncology, P.A. TX Onc | Dallas, Texas 75251 |
University of Texas Southwestern Medical Center UTSW 6 | Dallas, Texas 75390-8527 |
Texas Oncology, P.A. Presbyterian Hospital (2) | Dallas, Texas 75246 |
ClinRx Research ClinRx Rearch (2) | Denton, Texas 76210 |
Texas Oncology, P.A. Texas Oncology Lewisville | Fort Worth, Texas 76104 |
Baylor College of Medicine Baylor College of Medicine (2) | Houston, Texas 77030 |
The Baylor College of Medicine/The Methodist Hospital The Methodist Hospital | Houston, Texas 77030 |
MD Anderson Cancer Center/University of Texas Dept of MD Anderson (16) | Houston, Texas 77030-4009 |
Cancer Care Centers of South Texas / HOAST CCC of So.TX- MedicalCenter(2) | San Antonio, Texas 78229 |
Veterans Hospital VA Med Ctr | White River Junction, Vermont 05009 |
Delta Oncology Associates | Portsmouth, Virginia 23704 |
Columbia Basin Hematology CBHO | Kennewick, Washington 99336 |
Yakima Valley Memorial Hospital North Star Lodge | Yakima, Washington 98902 |
Charleston Area Medical Center David Lee Cancer Center | Charleston, West Virginia 25304 |
University of California at Los Angeles UCLA | Los Angeles, California 90095 |
University of California at San Diego, Moores Cancer Ctr Dept. of MooresCancerCenter(3) | San Diego, California 92103 |
Stanford University Medical Center Division of Hematology 2 | Stanford, California 94304 |
Georgia Regents University SC | Augusta, Georgia 30912 |
Cedar Valley Medical Specialsts Dept of Oncology | Waterloo, Iowa 50701 |
Kansas City Cancer Center KCCC - South | Overland Park, Kansas 66210 |
LSU HEALTH SCIENCES CENTER/ LSU SCHOOL OF MEDICINE Willis-Knighton Cancer Center | New Orleans, Louisiana 70115 |
University of Maryland Medical Center SC-2 | Baltimore, Maryland 21201 |
Cancer and Hematology Centers of Western Michigan, PC Dept of Oncology | Grand Rapids, Michigan 49546 |
Mercy Medical Research Institute SC | Manchester, Missouri 63021 |
Glacier View Research Institute - Cancer SC | Kalispell, Montana 59901 |
Mid Dakota Clinic, P.C. Dept of Oncology | Bismark, North Dakota 58501 |