Inclusion Criteria:

- Patients or volunteers with or without a history of melanoma.

- One or more palpable skin or subcutaneous lesions for which at least one of the
following is true:

- A tissue diagnosis has been made for the lesion(s) in question, by prior
cytologic or histologic evaluation (Category A1).

- A tissue diagnosis will be obtained for the lesion(s) in question by cytologic
or histologic evaluation (Category A2).

- A tissue diagnosis is not available, but a clinical diagnosis of melanoma or
benign lesion is available with a high degree of confidence. Examples are
hemangiomas, skin tags, seborrheic keratoses, dermatofibromas, lipomas, or
growing pigmented skin lesions that are comparable to other cutaneous metastases
of melanoma in the same patient (Category B).

- All patients must have the ability and willingness to give informed consent and must
be age 18 years or older at the time of study entry.

Exclusion Criteria:

- Known or suspected allergy to the adhesive skin markers or water-soluble ink used for
the labeling of lesions.

- Very fragile skin that may be susceptible to injury from adhesive markers.

- Patients in whom there is a medical contraindication or potential problem in
complying with the requirements of the protocol, in the opinion of the investigator.