Inclusion Criteria:

- Relapsed or refractory advanced solid tumor(s) and have exhausted standard treatment
options or no standard therapy exists

- Must have a sufficient window of time to complete the washout period, dosimetry data
acquisition and the follow up safety assessment period

- ECOG performance status of 0 or 1 and estimated life expectancy of ≥ 4 months

- 18 years or older

- Must be compliant with the protocol and be within geographical proximity to make the
required study visits

- Have the ability to read, understand and provide written informed consent

- Patients with brain metastasis are acceptable if the clinical condition has been
stable for at least one month

- Female patients of childbearing potential must have a negative serum pregnancy test
within 24 hours of start of treatment

- Must agree to use an effective method of contraception during the study and for 90
days following the last dose of study drug

Exclusion Criteria:

- Patient or physician plans concomitant chemotherapy, therapeutic radiation
treatment, and/or biological treatment for cancer including immunotherapy while on
study

- More than 25% of the total bone marrow irradiated

- Diffuse lung disease or interstitial spread of carcinoma

- Bladder or rectum is within a prior radiation therapy field and a dose of greater
than 45 Gy was administered

- Total therapeutic radiation dose in the past year in excess of 25 Gy to the kidney,
45 Gy to brain, 45 Gy to stomach, 18 Gy to lung, or 25 Gy to liver

- Prior total-body irradiation

- Extradural tumor in contact with the spinal cord, or tumor located where swelling in
response to therapy may impinge upon the spinal cord

- Prior radiation therapy or chemotherapy within 2 weeks of the start of the study

- Active medical condition(s) or organ disease(s) that may either compromise patient
safety or interfere with the safety and/or outcome evaluation of the study drug

- Laboratory values ≤ 7 days:

- WBC < 3000/µL

- Absolute neutrophil count < 1500/µL

- Platelets < 150,000/µL

- Hemoglobin ≤ 11.0 gm/dL

- Total bilirubin > 1.5 x upper limit of normal for age

- SGOT or SGPT > 3 x upper limit of normal for age if no liver metastases or > 5
x upper limit of normal for age in the presence of liver metastases

- Serum creatinine > 1.5 x upper limit of normal for age

- INR ≥ 2.0

- Investigational drug, investigational biologic, or investigational therapeutic device
within 30 days of initiating study drug

- Severely marrow toxic drugs (e.g. nitrosoureas, mitomycin)

- Prior treatment with Iodine-131 in the past five years

- Concurrent hemodialysis

- Blood transfusions within 60 days of study start

- Hematopoietic growth factor therapy within 60 days of study start

- Prior stem cell transplantation

- Clinically evident ascites or with peritoneal carcinomatosis

- Clinically significant cardiac co-morbidities including: CHF, a LVEF< 40%, unstable
angina pectoris, serious cardiac arrhythmia requiring medication or a pacemaker,
myocardial infarction within the past six months

- Clinically significant pulmonary impairment defined as an SaO2 on room air of 93% or
less

- Concurrent or recent use of thrombolytic agents, or full-dose anticoagulants

- Uncontrolled hypertension or patients with uncontrolled diabetes

- Grade II-IV peripheral vascular disease or peripheral vascular surgery within the
past year

- Less than 4 weeks since prior major surgery

- Known positive for HIV, Hepatitis C (active, previously treated or both), or is
Hepatitis B core antigen positive

- Concurrent chronic use of aspirin (325 mg/day or more)

- Pregnant or lactating

- Patients with colostomy/ileostomy

- Poor venous access

- Prior allergic reactions to iodine, or other study agents

- Significant traumatic injury within the past 4 weeks

- Ongoing or active infection requiring antibiotics or with a fever >38.1°C (>101° F)
within 3 days of the first scheduled day of dosing

- Patients who are hospitalized