Inclusion Criteria:

- Histologically or cytologically confirmed advanced measurable or evaluable solid
tumors unresponsive to currently available therapies, or for which there is no
curative therapy

- Eastern Cooperative Oncology Group (ECOG) performance status 0 and 1

- Life expectancy more than12 weeks

- Adequate bone marrow, liver and renal function

Exclusion Criteria:

- Known brain metastasis

- Chemotherapy, radiotherapy, or any investigational cancer therapy within 4 weeks of
start of screening procedures

- Major surgical procedure within 4 weeks of start of screening procedures

- Active bleeding disorder, including gastrointestinal bleeding, as evidenced by
hematemesis, significant hemoptysis or melena in the past 6 months