Assessment of Changes in Pattern and Magnitude of Tumor FDG Uptake During Chemoradiation as a Predictor of Response to Concurrent Radiation Therapy and Chemotherapy in Patients With Cervical Cancer

Inclusion Criteria:

1. Biopsy-proven cervical cancer. (FIGO stage-Ib2-IVa)

2. Age ≥ 18

3. Able to receive chemoradiation therapy with Cisplatin.

4. Non-pregnant status in women of childbearing potential.

5. No other active cancer at the time of diagnosis of cervical cancer Patients cannot
have received treatment for any malignancy, with the exception of non-melanoma skin
cancer, in the past 5 years.

6. Patients with distant metastatic disease are eligible provided the estimated survival
of the patient is at least 1 year.

7. Scheduled to undergo or have already undergone FDG-PET/CT imaging for clinical
staging of cervical cancer at Barnes-Jewish Hospital Clinical PET Facility on a
Biograph 40 PET/CT scanner

8. Able to give informed consent

Exclusion Criteria:

1. Age < 18

2. Patients with a known active malignancy other than cervical carcinoma.

3. Pregnant and breastfeeding patients.

4. Subjects whose tumors are not FDG avid on baseline standard of care FDG-PET/CT
imaging