Serum Biomarkers for Head and Neck Cancer
18 Years
N/A
Both
Head and Neck Cancer
Trial Information
Serum Biomarkers for Head and Neck Cancer
OBJECTIVES:
- Correlate the differences in serum protein profiles with the differences in the number
of peptide matches in patients with squamous cell carcinoma of the head and neck and in
healthy volunteers.
- Correlate protein levels with the largest difference in peptide matches in sera in
these participants.
OUTLINE: This is a prospective study.
Participants undergo blood, tissue, and saliva collection for biological studies. Samples
are analyzed for albumin-bound and non-albumin-bound proteins or IgG via liquid
chromatography and tandem mass spectrometry (LC-MS-MS), ELISA, proteomic profiling, and
protein expression.
PROJECTED ACCRUAL: A total of 50 patients and 50 healthy volunteers will be accrued for this
study.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Meets one of the following criteria:
- Diagnosis of squamous cell carcinoma of the head and neck
- Healthy volunteer matched by sex, race, birth decade, or smoking status (e.g.,
current smoker, former smoker, or nonsmoker)
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Differences in serum protein profiles and differences in the number of peptide matches
Safety Issue:
No
Principal Investigator
Wendell G. Yarbrough, MD, FACS
Investigator Role:
Study Chair
Investigator Affiliation:
Vanderbilt-Ingram Cancer Center
Authority:
Unspecified
Study ID:
CDR0000546781
NCT ID:
NCT00899769
Start Date:
April 2005
Completion Date:
Related Keywords:
- Head and Neck Cancer
- metastatic squamous neck cancer with occult primary squamous cell carcinoma
- recurrent squamous cell carcinoma of the hypopharynx
- recurrent squamous cell carcinoma of the larynx
- recurrent squamous cell carcinoma of the lip and oral cavity
- recurrent squamous cell carcinoma of the nasopharynx
- recurrent squamous cell carcinoma of the oropharynx
- recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage I squamous cell carcinoma of the hypopharynx
- stage I squamous cell carcinoma of the larynx
- stage I squamous cell carcinoma of the lip and oral cavity
- stage I squamous cell carcinoma of the nasopharynx
- stage I squamous cell carcinoma of the oropharynx
- stage I squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage II squamous cell carcinoma of the hypopharynx
- stage II squamous cell carcinoma of the larynx
- stage II squamous cell carcinoma of the lip and oral cavity
- stage II squamous cell carcinoma of the nasopharynx
- stage II squamous cell carcinoma of the oropharynx
- stage II squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage III squamous cell carcinoma of the hypopharynx
- stage III squamous cell carcinoma of the larynx
- stage III squamous cell carcinoma of the lip and oral cavity
- stage III squamous cell carcinoma of the nasopharynx
- stage III squamous cell carcinoma of the oropharynx
- stage III squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage IV squamous cell carcinoma of the hypopharynx
- stage IV squamous cell carcinoma of the larynx
- stage IV squamous cell carcinoma of the lip and oral cavity
- stage IV squamous cell carcinoma of the nasopharynx
- stage IV squamous cell carcinoma of the oropharynx
- stage IV squamous cell carcinoma of the paranasal sinus and nasal cavity
- untreated metastatic squamous neck cancer with occult primary
- recurrent metastatic squamous neck cancer with occult primary
- recurrent salivary gland cancer
- salivary gland squamous cell carcinoma
- stage I salivary gland cancer
- stage II salivary gland cancer
- stage III salivary gland cancer
- stage IV salivary gland cancer
- Head and Neck Neoplasms
Name | Location |
|---|---|
| Vanderbilt-Ingram Cancer Center | Nashville, Tennessee 37232-6838 |
| Vanderbilt-Ingram Cancer Center - Cool Springs | Nashville, Tennessee 37064 |
| Vanderbilt-Ingram Cancer Center at Franklin | Nashville, Tennessee 37064 |
