Identification and Validation of Molecular Markers in Lung Cancer

Inclusion Criteria

DISEASE CHARACTERISTICS:

- Meets 1 of the following criteria:

- Known or previously diagnosed lung cancer

- Suspected lung cancer, including the following:

- Completely resected stage I lung cancer (with no evidence of metastatic
disease) for which patient is at risk for developing secondary disease

- Suspected of having lung cancer due to clinical symptoms, such as positive
sputum cytology, hemoptysis, unresolved pneumonia, persistent cough, and
positive x-ray

- Healthy volunteer

PATIENT CHARACTERISTICS:

- WBC ≥ 2,000/mm³ but ≤ 20,000/mm³

- Platelet count ≥ 50,000/mm³

- Not pregnant

- No uncontrolled hypertension (i.e., systolic blood pressure > 200 mm Hg, diastolic
blood pressure > 120 mm Hg)

- No unstable angina

- No known bleeding disorder

- No other contraindications for white light bronchoscopic examination

- No other contraindications for fluorescence examination

PRIOR CONCURRENT THERAPY:

- More than 3 months since prior fluorescent photosensitizing agents (hematoporphyrin
derivatives)

- More than 3 months since prior and no concurrent chemopreventative drugs (e.g.,
tretinoin)

- More than 6 months since prior ionizing radiation treatment to the chest

- More than 6 months since prior systemic cytotoxic chemotherapy

- No concurrent anticoagulant therapy