Using the Transcriptome for Early Detection of Graft Versus Host Disease in Allogeneic Bone Marrow Transplantation

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Identification of changes in the transcriptome or proteome expression prior to clinical manifestations of graft-versus-host disease (GVHD) in patient blood samples

Outcome Description:

Once a minimum of 20 patients have been enrolled and clinically are beyond their period of risk of developing acute GVHD, samples from at least 5 patients who have developed acute GVHD are compared to samples from at least 5 patients who have had no detectable clinical GVHD. If no differences are detected, additional patients/samples will be enrolled/analyzed.

Outcome Time Frame:

Patients beyond period of risk for developing acute GVHD

Safety Issue:

No

Principal Investigator

Roberta Adams, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Mayo Clinic Hospital

Authority:

United States: Institutional Review Board

Study ID:

CDR0000588925

NCT ID:

NCT00898612

Start Date:

March 2008

Completion Date:

Related Keywords:

• Lymphoma
• stage III adult Burkitt lymphoma
• stage III adult diffuse large cell lymphoma
• stage III adult diffuse mixed cell lymphoma
• stage III adult diffuse small cleaved cell lymphoma
• stage III adult Hodgkin lymphoma
• stage III adult immunoblastic large cell lymphoma
• stage III adult lymphoblastic lymphoma
• stage III grade 1 follicular lymphoma
• stage III grade 2 follicular lymphoma
• stage III grade 3 follicular lymphoma
• stage III mantle cell lymphoma
• stage III marginal zone lymphoma
• stage III small lymphocytic lymphoma
• stage IV adult Burkitt lymphoma
• stage IV adult diffuse large cell lymphoma
• stage IV adult diffuse mixed cell lymphoma
• stage IV adult diffuse small cleaved cell lymphoma
• stage IV adult Hodgkin lymphoma
• stage IV adult immunoblastic large cell lymphoma
• stage IV adult lymphoblastic lymphoma
• stage IV grade 1 follicular lymphoma
• stage IV grade 2 follicular lymphoma
• stage IV grade 3 follicular lymphoma
• stage IV mantle cell lymphoma
• stage IV marginal zone lymphoma
• stage IV small lymphocytic lymphoma
• recurrent adult Burkitt lymphoma
• recurrent adult diffuse large cell lymphoma
• recurrent adult diffuse mixed cell lymphoma
• recurrent adult diffuse small cleaved cell lymphoma
• recurrent adult Hodgkin lymphoma
• recurrent adult immunoblastic large cell lymphoma
• recurrent adult lymphoblastic lymphoma
• recurrent childhood large cell lymphoma
• recurrent childhood lymphoblastic lymphoma
• recurrent childhood small noncleaved cell lymphoma
• recurrent cutaneous T-cell non-Hodgkin lymphoma
• recurrent grade 1 follicular lymphoma
• recurrent grade 2 follicular lymphoma
• recurrent grade 3 follicular lymphoma
• recurrent mantle cell lymphoma
• recurrent marginal zone lymphoma
• recurrent small lymphocytic lymphoma
• recurrent/refractory childhood Hodgkin lymphoma
• recurrent mycosis fungoides/Sezary syndrome
• extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
• nodal marginal zone B-cell lymphoma
• splenic marginal zone lymphoma
• noncontiguous stage II adult Burkitt lymphoma
• noncontiguous stage II adult diffuse large cell lymphoma
• noncontiguous stage II adult diffuse mixed cell lymphoma
• noncontiguous stage II adult diffuse small cleaved cell lymphoma
• noncontiguous stage II adult immunoblastic large cell lymphoma
• noncontiguous stage II adult lymphoblastic lymphoma
• noncontiguous stage II grade 1 follicular lymphoma
• noncontiguous stage II grade 2 follicular lymphoma
• noncontiguous stage II grade 3 follicular lymphoma
• noncontiguous stage II mantle cell lymphoma
• noncontiguous stage II marginal zone lymphoma
• noncontiguous stage II small lymphocytic lymphoma
• accelerated phase chronic myelogenous leukemia
• adult acute lymphoblastic leukemia in remission
• adult acute myeloid leukemia in remission
• adult acute myeloid leukemia with 11q23 (MLL) abnormalities
• adult acute myeloid leukemia with inv(16)(p13;q22)
• adult acute myeloid leukemia with t(15;17)(q22;q12)
• adult acute myeloid leukemia with t(16;16)(p13;q22)
• adult acute myeloid leukemia with t(8;21)(q22;q22)
• atypical chronic myeloid leukemia, BCR-ABL negative
• blastic phase chronic myelogenous leukemia
• childhood acute lymphoblastic leukemia in remission
• childhood acute myeloid leukemia in remission
• childhood chronic myelogenous leukemia
• chronic myelomonocytic leukemia
• chronic phase chronic myelogenous leukemia
• juvenile myelomonocytic leukemia
• recurrent adult acute lymphoblastic leukemia
• recurrent adult acute myeloid leukemia
• recurrent childhood acute lymphoblastic leukemia
• recurrent childhood acute myeloid leukemia
• refractory chronic lymphocytic leukemia
• refractory hairy cell leukemia
• relapsing chronic myelogenous leukemia
• secondary acute myeloid leukemia
• stage III chronic lymphocytic leukemia
• stage IV chronic lymphocytic leukemia
• childhood myelodysplastic syndromes
• chronic eosinophilic leukemia
• primary myelofibrosis
• chronic neutrophilic leukemia
• de novo myelodysplastic syndromes
• disseminated neuroblastoma
• myelodysplastic/myeloproliferative neoplasm, unclassifiable
• poor prognosis metastatic gestational trophoblastic tumor
• previously treated childhood rhabdomyosarcoma
• previously treated myelodysplastic syndromes
• recurrent Wilms tumor and other childhood kidney tumors
• recurrent childhood rhabdomyosarcoma
• recurrent neuroblastoma
• recurrent ovarian epithelial cancer
• recurrent ovarian germ cell tumor
• recurrent malignant testicular germ cell tumor
• secondary myelodysplastic syndromes
• stage I multiple myeloma
• stage II multiple myeloma
• stage III multiple myeloma
• stage II ovarian epithelial cancer
• stage III ovarian epithelial cancer
• stage IV ovarian epithelial cancer
• stage III malignant testicular germ cell tumor
• stage IIIA breast cancer
• stage IIIB breast cancer
• stage IIIC breast cancer
• stage IV breast cancer
• refractory multiple myeloma
• Graft vs Host Disease
• Lymphoma
• Lymphoma, Non-Hodgkin
• Lymphoma, Large-Cell, Immunoblastic