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Molecular Predictors of Lung Cancer Behavior


N/A
18 Years
N/A
Open (Enrolling)
Both
Lung Cancer

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Trial Information

Molecular Predictors of Lung Cancer Behavior


OBJECTIVES:

- To use fixed lung tissue for histological evaluation and fresh tissue samples for
molecular studies to study DNA, RNA, and protein abnormalities in lung preneoplastic
and neoplastic lesions.

- To use proteomic techniques, including matrix-assisted laser desorption ionization-mass
spectrometry (MALDI-MS), to develop a method of diagnosing and staging both
pre-invasive and invasive lesions, using less invasive methods.

OUTLINE: Blood, urine, nasal cell, and sputum samples are collected. Lung tissue samples are
also collected using fluorescence bronchoscopy and epithelial cell collection.

Samples are studied by genetic and proteomic analyses, including comparative genomic
hybridization, expression microarray, and protein profiling.


Inclusion Criteria:



-All adults referred to Vanderbilt Medical Center, Veterans Administration Medical Center,
St. Thomas Hospital and Meharry Medical Center for evaluation of signs or symptoms of lung
cancer.

Exclusion Criteria:

- Inability to provide informed consent

- Minors

- Pregnant women

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

To quantitate the molecular changes during lung cancer development

Outcome Description:

As a part of the study nasal brushing specimens, sputum, blood, urine, and a small amount of other tissue will be collected during standard of care procedures (bronchial epithelial, trans-thoracic fine needle aspiration (FNA) and thoracentesis as part of patient work up. Clinical diagnosis is the primary goal of the procedure. All the research specimens are collected after the primary goal of the procedure is met.

Outcome Time Frame:

After collection of designated samples

Safety Issue:

No

Principal Investigator

Pierre P. Massion, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Vanderbilt-Ingram Cancer Center

Authority:

Unites States: Vanderbilt University Human Reserach Protection Program

Study ID:

VICC THO 0398

NCT ID:

NCT00898313

Start Date:

December 2003

Completion Date:

January 2017

Related Keywords:

  • Lung Cancer
  • lung cancer
  • Lung Neoplasms

Name

Location
Vanderbilt-Ingram Cancer Center Nashville, Tennessee  37232-6838
Veterans Affairs Medical Center - Nashville Nashville, Tennessee  37212
Vanderbilt-Ingram Cancer Center - Cool Springs Nashville, Tennessee  37064
Vanderbilt-Ingram Cancer Center at Franklin Nashville, Tennessee  37064