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Optimizing EGFR Inhibitor-Based Therapies for GBM


N/A
18 Years
N/A
Open (Enrolling)
Both
Brain and Central Nervous System Tumors

Thank you

Trial Information

Optimizing EGFR Inhibitor-Based Therapies for GBM


OBJECTIVES:

Primary

- Identify molecular characteristics that predict for overall survival and
progression-free survival of patients treated with erlotinib hydrochloride,
temozolomide, and radiotherapy on clinical trial NCCTG-N0177.

Secondary

- Identify molecular characteristics that predict for overall survival and
progression-free survival of patients treated with gefitinib after radiotherapy on
clinical trial NCCTG-N0074.

OUTLINE: This is a multicenter study.

Tissue samples from patients enrolled on clinical trials NCCTG-N0177 or NCCTG-N0074 are
analyzed by microarray analysis and immunohistochemistry for biological markers predicting
progression-free survival and overall survival. Biological markers include epidermal growth
factor expression, vIII mutant p53 gene, P-AKT, p7056k, S6, 4EBP1, STAT-3, PLC-g, Erk,
ErbB2, ErbB3, ErbB4, platelet-derived growth factor receptor, IGF1R, interleukin-6, FADD,
and MGMT.

PROJECTED ACCRUAL: A total of 120 patients will be accrued for this study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Enrolled on clinical trials NCCTG-N0177 or NCCTG-N0074

- Must have appropriate archived clinical specimens

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Molecular characteristics that predict for overall survival and progression-free survival

Safety Issue:

No

Principal Investigator

Jann N. Sarkaria, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Mayo Clinic

Authority:

Unspecified

Study ID:

CDR0000527337

NCT ID:

NCT00897663

Start Date:

November 2006

Completion Date:

Related Keywords:

  • Brain and Central Nervous System Tumors
  • adult giant cell glioblastoma
  • adult gliosarcoma
  • adult glioblastoma
  • Glioblastoma
  • Nervous System Neoplasms
  • Central Nervous System Neoplasms

Name

Location
Mayo Clinic Scottsdale Scottsdale, Arizona  85259
Mayo Clinic - Jacksonville Jacksonville, Florida  32224
Mayo Clinic Cancer Center Rochester, Minnesota  55905
Mercy Medical Center - Sioux City Sioux City, Iowa  51104
Siouxland Hematology-Oncology Associates, LLP Sioux City, Iowa  51101
St. Luke's Regional Medical Center Sioux City, Iowa  51104
Rapid City Regional Hospital Rapid City, South Dakota  57709
Mid Dakota Clinic, PC Bismarck, North Dakota  58501
Medcenter One Hospital Cancer Care Center Bismarck, North Dakota  58501
St. Alexius Medical Center Cancer Center Bismarck, North Dakota  58502