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Acquisition of Human Gynecologic Specimens to be Used in Studying the Causes, Diagnosis, Prevention and Treatment of Cancer


N/A
N/A
N/A
Open (Enrolling)
Female
Cancer

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Trial Information

Acquisition of Human Gynecologic Specimens to be Used in Studying the Causes, Diagnosis, Prevention and Treatment of Cancer


OBJECTIVES:

- Collect gynecological tumor specimens and blood from patients at GOG institutions.

- Provide a repository for long-term storage of these specimens.

OUTLINE: Snap frozen tumor tissue, OCT molds of tumor tissue, formalin-preserved tumor
tissue, buffy coat-prepared tumor tissue, and blood samples are collected and stored in the
repository. Patient information is kept confidential, and patients are not informed of any
research/test results from use of their tissues.

PROJECTED ACCRUAL: Not specified

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Any of the following:

- Patients who have had gynecologic tissue removed during surgery to diagnosis,
treat, monitor, and/or prevent primary, persistent, or recurrent gynecologic
cancer of the ovary, peritoneum, fallopian tube, cervix, uterine corpus, vagina,
or vulva, meeting at least one of the following criteria:

- Group A: Women who underwent surgery, were diagnosed with a primary
gynecologic malignancy of the ovary, cervix, uterine corpus, or vulva, and
have primary tumor, normal tissue, and blood available for submission for
this protocol

- Patients with ovarian cancer including all stages, grades, and common
epithelial cell types

- Invasive cancers and serous and mucinous borderline tumors of low
malignant potential are allowed

- At least 1 gram of frozen primary tumor tissue must be submitted
for this protocol for patients with FIGO stage III or IV
epithelial ovarian cancer

- Patients with an invasive malignancy of the cervix or uterine corpus
including all stages, grades, and common cell types

- Patients with squamous cell carcinoma of the vulva

- Group B: Women who underwent surgery and were diagnosed with a rare
gynecologic malignancy of the ovary, peritoneum, fallopian tube, cervix,
uterine corpus, vagina, vulva, a gestational trophoblastic tumor, or a
tumor arising in endometriosis, and have tumor tissue available for
submission for this protocol

- Patients with a rare gynecologic malignancy of the ovary including
malignant germ cell tumors; sex cord-stromal tumors; malignant mixed
mesodermal tumors; clear cell, mucinous, small cell, or transitional
cell carcinomas; malignant Brenner tumors; or borderline tumors of low
malignant potential (except serous and mucinous)

- Patients with a rare gynecologic malignancy of the peritoneum,
including primary peritoneal cancer or mesothelioma

- Patients with carcinoma of the fallopian tube

- Patients with a rare gynecologic malignancy of the cervix including
verrucous, small cell, clear cell, serous, or adenoid cystic
carcinomas; carcinoid tumors; malignant mixed mesodermal tumors; or
leiomyosarcoma

- Patients with a rare gynecologic malignancy of the uterine corpus
including leiomyosarcoma; malignant mixed mesodermal tumors;
endometrial stromal sarcomas; smooth muscle tumors of unknown
malignant potential; or clear cell or small cell carcinomas

- Patients with a rare gynecologic malignancy of the vagina including
verrucous or clear cell carcinomas; melanoma; embryonal
rhabdomyosarcoma; or endodermal sinus tumor

- Patients with a rare gynecologic malignancy of the vulva including
verrucous carcinoma; melanoma; aggressive angiomyxoma; sarcoma;
malignant Paget's disease; or Bartholin gland carcinoma

- Patients with a gestational trophoblastic tumor

- Patients with a tumor arising in endometriosis

- Group C: Women who underwent prophylactic oophorectomy and have at least 1
gram of ovarian tissue and blood available for submission for this protocol

- Group D: Women who underwent surgery to monitor or treat a persistent or
recurrent gynecologic malignancy of the ovary, peritoneum, fallopian tube,
cervix, uterine corpus, vagina, or vulva, and have persistent or recurrent
tumor, normal tissue, and blood available for submission for this protocol

- Concurrent primary cancers are allowed

- No benign cystic tumors of the ovary, including cystic epithelial tumors and mature
cystic teratomas

PATIENT CHARACTERISTICS: Not specified

PRIOR CONCURRENT THERAPY:

Chemotherapy:

- Prior cytotoxic chemotherapy allowed

Endocrine therapy:

- Prior hormonal therapy allowed

Radiotherapy:

- Prior radiotherapy allowed

Surgery:

- Prior surgery allowed

- No more than 6 weeks after prior surgery

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Collection of gynecological tumor specimens and serum from patients at GOG institutions

Safety Issue:

No

Principal Investigator

Michael L. Cibull, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Lucille P. Markey Cancer Center at University of Kentucky

Authority:

Unspecified

Study ID:

CDR0000078647

NCT ID:

NCT00897442

Start Date:

June 1992

Completion Date:

Related Keywords:

  • Cancer
  • childhood malignant ovarian germ cell tumor
  • ovarian serous cystadenocarcinoma
  • ovarian serous cystadenoma with proliferating activity
  • recurrent ovarian germ cell tumor
  • recurrent ovarian epithelial cancer
  • stage IV ovarian epithelial cancer
  • stage III borderline ovarian surface epithelial-stromal tumor
  • stage IV borderline ovarian surface epithelial-stromal tumor
  • uterine corpus cancer
  • cervical adenocarcinoma
  • cervical adenosquamous cell carcinoma
  • cervical small cell carcinoma
  • cervical squamous cell carcinoma
  • recurrent cervical cancer
  • stage IA cervical cancer
  • stage IB cervical cancer
  • stage IIA cervical cancer
  • stage IIB cervical cancer
  • stage III cervical cancer
  • stage IVA cervical cancer
  • stage IVB cervical cancer
  • squamous cell carcinoma of the vulva
  • Brenner tumor
  • malignant mesothelioma
  • uterine leiomyosarcoma
  • endometrial stromal sarcoma
  • neoplasm of uncertain malignant potential
  • melanoma
  • embryonal childhood rhabdomyosarcoma
  • Paget disease of the vulva
  • gestational trophoblastic tumor
  • ovarian stromal cancer
  • ovarian clear cell cystadenocarcinoma
  • ovarian clear cell tumor with proliferating activity
  • stage IA ovarian germ cell tumor
  • stage IB ovarian germ cell tumor
  • stage IC ovarian germ cell tumor
  • stage IIA ovarian germ cell tumor
  • stage IIB ovarian germ cell tumor
  • stage IIC ovarian germ cell tumor
  • stage IIIA ovarian germ cell tumor
  • stage IIIB ovarian germ cell tumor
  • stage IIIC ovarian germ cell tumor
  • stage IA ovarian epithelial cancer
  • stage IB ovarian epithelial cancer
  • stage IC ovarian epithelial cancer
  • stage IIA ovarian epithelial cancer
  • stage IIB ovarian epithelial cancer
  • stage IIC ovarian epithelial cancer
  • stage IIIA ovarian epithelial cancer
  • stage IIIB ovarian epithelial cancer
  • stage IIIC ovarian epithelial cancer
  • recurrent primary peritoneal cavity cancer
  • stage IA primary peritoneal cavity cancer
  • stage IB primary peritoneal cavity cancer
  • stage IC primary peritoneal cavity cancer
  • stage IIA primary peritoneal cavity cancer
  • stage IIB primary peritoneal cavity cancer
  • stage IIC primary peritoneal cavity cancer
  • stage IIIA primary peritoneal cavity cancer
  • stage IIIB primary peritoneal cavity cancer
  • stage IIIC primary peritoneal cavity cancer
  • stage IV primary peritoneal cavity cancer
  • recurrent fallopian tube cancer
  • stage IA fallopian tube cancer
  • stage IB fallopian tube cancer
  • stage IC fallopian tube cancer
  • stage IIA fallopian tube cancer
  • stage IIB fallopian tube cancer
  • stage IIC fallopian tube cancer
  • stage IIIA fallopian tube cancer
  • stage IIIB fallopian tube cancer
  • stage IIIC fallopian tube cancer
  • stage IV fallopian tube cancer
  • recurrent endometrial carcinoma
  • stage I endometrial carcinoma
  • stage II endometrial carcinoma
  • stage III endometrial carcinoma
  • stage IV endometrial carcinoma
  • recurrent vaginal cancer
  • stage I vaginal cancer
  • stage II vaginal cancer
  • stage III vaginal cancer
  • stage IVA vaginal cancer
  • stage IVB vaginal cancer
  • recurrent vulvar cancer
  • stage I vulvar cancer
  • stage II vulvar cancer
  • stage III vulvar cancer
  • stage IVB vulvar cancer

Name

Location

National Naval Medical Center Bethesda, Maryland  20889
Fred Hutchinson Cancer Research Center Seattle, Washington  98109
University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan  48109-0752
Barbara Ann Karmanos Cancer Institute Detroit, Michigan  48201
CCOP - Iowa Oncology Research Association Des Moines, Iowa  50309-1016
George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus New Britain, Connecticut  06050
Baystate Regional Cancer Program at D'Amour Center for Cancer Care Springfield, Massachusetts  01199
Case Comprehensive Cancer Center Cleveland, Ohio  44106-5065
Sanford Cancer Center at Sanford USD Medical Center Sioux Falls, South Dakota  57117-5039
Avera Cancer Institute Sioux Falls, South Dakota  57105
Vanderbilt-Ingram Cancer Center Nashville, Tennessee  37232-6838
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center Madison, Wisconsin  53792-6164
Marshfield Clinic - Marshfield Center Marshfield, Wisconsin  54449
Medical College of Wisconsin Cancer Center Milwaukee, Wisconsin  53226
Marshfield Clinic - Indianhead Center Rice Lake, Wisconsin  54868
CCOP - Cancer Research for the Ozarks Springfield, Missouri  65807
CCOP - Greenville Greenville, South Carolina  29615
University of Texas Medical Branch Galveston, Texas  77555-1329
Virginia Mason Medical Center Seattle, Washington  98111
Holden Comprehensive Cancer Center at University of Iowa Iowa City, Iowa  52242-1002
UMASS Memorial Cancer Center - University Campus Worcester, Massachusetts  01605-2982
Ellis Fischel Cancer Center at University of Missouri - Columbia Columbia, Missouri  65203
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire  03756-0002
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill Chapel Hill, North Carolina  27599-7570
Charles M. Barrett Cancer Center at University Hospital Cincinnati, Ohio  45267-0526
UPMC Cancer Center at Magee-Womens Hospital Pittsburgh, Pennsylvania  15213-3180
MultiCare Regional Cancer Center at Tacoma General Hospital Tacoma, Washington  98405
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland  21231-2410
Cleveland Clinic Taussig Cancer Center Cleveland, Ohio  44195
Brooke Army Medical Center Fort Sam Houston, Texas  78234-6200
CCOP - Virginia Mason Research Center Seattle, Washington  98101
Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center Milwaukee, Wisconsin  53201-2901
University of California Davis Cancer Center Sacramento, California  95817
Fletcher Allen Health Care - University Health Center Campus Burlington, Vermont  05401
John Stoddard Cancer Center at Iowa Methodist Medical Center Des Moines, Iowa  50309
Sunrise Hospital and Medical Center Las Vegas, Nevada  89109-2306
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences Little Rock, Arkansas  72205
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus Seattle, Washington  98104
Northside Hospital Cancer Center Atlanta, Georgia  30342-1611
St. John's Regional Health Center Springfield, Missouri  65804
Winthrop University Hospital Mineola, New York  11501
McDowell Cancer Center at Akron General Medical Center Akron, Ohio  44307
Lake/University Ireland Cancer Center Mentor, Ohio  44060
Women and Infants Hospital of Rhode Island Providence, Rhode Island  02905
Carilion Gynecologic Oncology Associates Roanoke, Virginia  24014
Wilford Hall Medical Center Lackland Air Force Base, Texas  78236-5300
Yale Cancer Center New Haven, Connecticut  06520-8028
Advocate Christ Medical Center Oak Lawn, Illinois  60453
Mount Sinai Medical Center New York, New York  10029
Stony Brook University Cancer Center Stony Brook, New York  11794-8174
Wake Forest University Comprehensive Cancer Center Winston-Salem, North Carolina  27157-1096
Hollings Cancer Center at Medical University of South Carolina Charleston, South Carolina  29425
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas Dallas, Texas  75390
Sibley Memorial Hospital Washington, District of Columbia  20016
St. Elizabeth Medical Center Edgewood, Kentucky  41017
Riverside Methodist Hospital Cancer Care Columbus, Ohio  43214
University Cancer Center at University of Washington Medical Center Seattle, Washington  98195
Jonsson Comprehensive Cancer Center at UCLA Los Angeles, California  90095-1781
UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California  94115
Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center Savannah, Georgia  31403-3089
University of Illinois Cancer Center Chicago, Illinois  60612-7243
Indiana University Melvin and Bren Simon Cancer Center Indianapolis, Indiana  46202-5289
Lucille P. Markey Cancer Center at University of Kentucky Lexington, Kentucky  40536-0093
University of Mississippi Cancer Clinic Jackson, Mississippi  39216-4505
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis St. Louis, Missouri  63110
University of New Mexico Cancer Center Albuquerque, New Mexico  87131-5636
Oklahoma University Cancer Institute Oklahoma City, Oklahoma  73104
Methodist Estabrook Cancer Center Omaha, Nebraska  68114-4199
Robert H. Lurie Comprehensive Cancer Center at Northwestern University Chicago, Illinois  60611
Todd Cancer Institute at Long Beach Memorial Medical Center Long Beach, California  90801
Maine Medical Center - Bramhall Campus Portland, Maine  04102
Cleveland Clinic Cancer Center at Fairview Hospital Cleveland, Ohio  44111
Hillcrest Cancer Center at Hillcrest Hospital Mayfield Heights, Ohio  44124
Cancer Care Associates - Saint Francis Campus Tulsa, Oklahoma  74136-1929
Rosenfeld Cancer Center at Abington Memorial Hospital Abington, Pennsylvania  19001
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest Allentown, Pennsylvania  18105
Fox Chase Cancer Center - Philadelphia Philadelphia, Pennsylvania  19111-2497
Parkland Memorial Hospital Dallas, Texas  75235
John Stoddard Cancer Center at Iowa Lutheran Hospital Des Moines, Iowa  50316-2301
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Des Moines, Iowa  50309
Medical Oncology and Hematology Associates at Mercy Cancer Center Des Moines, Iowa  50314
Mercy Cancer Center at Mercy Medical Center - Des Moines Des Moines, Iowa  50314
Medical Oncology and Hematology Associates - West Des Moines West Des Moines, Iowa  50266
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital Pittsburgh, Pennsylvania  15224-1791
Praxair Cancer Center at Danbury Hospital Danbury, Connecticut  06810
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center Columbus, Ohio  43210-1240
Legacy Good Samaritan Hospital & Comprehensive Cancer Center Portland, Oregon  97210
Northwest Cancer Specialists at Rose Quarter Cancer Center Portland, Oregon  97227
Marshfield Clinic - Chippewa Center Chippewa Falls, Wisconsin  54729
Marshfield Clinic Cancer Care at Regional Cancer Center Eau Claire, Wisconsin  54701
Saint Joseph's Hospital Marshfield, Wisconsin  54449
Marshfield Clinic - Lakeland Center Minocqua, Wisconsin  54548
Marshfield Clinic at Saint Michael's Hospital Stevens Point, Wisconsin  54481
Saint Michael's Hospital Cancer Center Stevens Point, Wisconsin  54481
Marshfield Clinic - Wausau Center Wausau, Wisconsin  54401
Marshfield Clinic - Weston Center Weston, Wisconsin  54476
Diagnostic and Treatment Center Weston, Wisconsin  54476
Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids, Wisconsin  54494
Woman's Hospital Baton Rouge, Louisiana  70815
FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center Pinehurst, North Carolina  28374
Fox Chase Cancer Center CCOP Research Base Philadelphia, Pennsylvania  19140
Seattle Cancer Care Alliance Seattle, Washington  98109
Regional Cancer Center at Memorial Medical Center Springfield, Illinois  62781-0001
Methodist Hospital Houston, Texas  77030
Aurora Sinai Medical Center Milwaukee, Wisconsin  53201-0342
Seton Shivers Cancer Program at Brackenridge Hospital Austin, Texas  78701
Cancer Centers of the Carolinas - Faris Road Greenville, South Carolina  29605
Cancer Centers of the Carolinas - Spartanburg Spartanburg, South Carolina  29307
Pacific Gynecology Specialists Seattle, Washington  98104
MBCCOP - Meharry Medical College - Nashville Nashville, Tennessee  37208-3599
Louisville Oncology at Norton Cancer Institute - Louisville Louisville, Kentucky  40202
Women's Cancer Center - La Canada Las Vegas, Nevada  89169
Good Samaritan Hospital Cancer Treatment Center Cincinnati, Ohio  45220
Olive View - UCLA Medical Center Foundation Sylmar, California  91342
University of Colorado Cancer Center at UC Health Sciences Center Aurora, Colorado  80045
Christus Schumpert Cancer Treatment Center Shreveport, Louisiana  71101
Florida Gynecologic Oncology - Fort Myers Fort Myers, Florida  33905
St. Dominic Cancer Center Jackson, Mississippi  39216
Black Hills Obstetrics & Gynecology LLP Rapid City, South Dakota  57701
Chattanooga's Program in Women's Oncology Chattanooga, Tennessee  37403
Aurora Women's Pavilion of West Allis Memorial Hospital West Allis, Wisconsin  53227
Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center Burbank, California  91505
Marshfield Clinic - Ladysmith Center Ladysmith, Wisconsin  54848
Mercy Cancer Center - West Lakes Clive, Iowa  50325
Methodist West Hospital West Des Moines, Iowa  50266-7700