Trial Information

Analysis of Intermediate Endpoint Biomarkers in the Respiratory Epithelium of Smokers Compared to Non-Smoking Controls

OBJECTIVES:

Primary

- Define the molecular and biochemical profiles of airway epithelium of smokers with no
disease, smokers with airflow obstruction and abnormal sputum cytology, and
non-smokers.

Secondary

- Assess the occurrence of abnormalities in non-smokers, smokers with no disease, smokers
with various grades of dysplasia, and smokers with lung cancer.

OUTLINE: Patients are stratified according to smoking status (smoker vs non-smoker) and
disease (no disease vs airflow obstruction and abnormal sputum cytology vs various grades of
dysplasia vs lung cancer).

Biological samples are collected and analyzed for future research studies.

PROJECTED ACCRUAL: A total of 78 patients will be accrued for this study.