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Identification of Target Genes for Diagnosis and Prognosis of AML Using a Custom-Design Microarray


N/A
N/A
N/A
Open (Enrolling)
Both
Leukemia

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Trial Information

Identification of Target Genes for Diagnosis and Prognosis of AML Using a Custom-Design Microarray


OBJECTIVES:

- To identify and validate individual genes for diagnosis of three major translocations
in acute myeloid leukemia.

- To correlate transcript expression data in the various translocations with age, sex,
race, response to treatment, and survival and with other known mutations.

OUTLINE: Blood and/or bone marrow samples previously procured from patients on CALGB-9665
are obtained from the CALGB Leukemia Tissue Bank from patients enrolled on CALGB AML
treatment studies. Mononuclear cells are isolated from samples and mRNA is extracted. Gene
expression profiles are analyzed via custom mRNA microarray and confirmed by quantitative
real-time PCR.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Enrolled on CALGB acute myeloid leukemia (AML) treatment studies AND concurrently
enrolled on Leukemia Tissue Bank Protocol CALGB-9665

- Short-term or long-term survivor

- Bone marrow and/or peripheral blood obtained at diagnosis

- Leukemia is one of the following cytogenetic subtypes:

- t(8;21)

- t(15;17)

- inv(16)

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Correlation of increased or decreased expression of same transcripts with disease outcome

Safety Issue:

No

Principal Investigator

Janet Rowley, MD

Investigator Role:

Study Chair

Investigator Affiliation:

University of Chicago

Authority:

Unspecified

Study ID:

CDR0000595708

NCT ID:

NCT00897182

Start Date:

May 2008

Completion Date:

Related Keywords:

  • Leukemia
  • adult acute myeloid leukemia in remission
  • adult acute myeloid leukemia with inv(16)(p13;q22)
  • adult acute myeloid leukemia with t(15;17)(q22;q12)
  • adult acute myeloid leukemia with t(8;21)(q22;q22)
  • childhood acute myeloid leukemia in remission
  • recurrent adult acute myeloid leukemia
  • recurrent childhood acute myeloid leukemia
  • secondary acute myeloid leukemia
  • untreated adult acute myeloid leukemia
  • untreated childhood acute myeloid leukemia and other myeloid malignancies
  • Leukemia
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid

Name

Location
Wayne Memorial Hospital, Incorporated Goldsboro, North Carolina  27534
Fort Wayne Medical Oncology and Hematology Fort Wayne, Indiana  46815