Safety Study to Determine the Maximum Tolerated Dose, Pharmacokinetics and Pharmacodynamics of Oral MP470, a Multitargeted Tyrosine Kinase Inhibitor, in Patients With Solid Malignancies

Inclusion Criteria:

1. The patient has a histological or cytological diagnosis of unresectable or metastatic
solid-tumor cancer that is refractory to standard therapies or for which no standard
therapy exists. Patients with refractory lymphoma (Hodgkin's or NHL) are also
permitted to participate.

2. The patient must read, understand and sign the IRB-approved informed consent form
(ICF) confirming his or her willingness to participate in this trial.

3. The patient is willing and able to participate in all of the required evaluations and
procedures described in this study protocol, including swallowing MP 470 capsules.

4. The patient is at least 18 years old.

5. The patient is capable of fasting for 6 hours.

6. The patient has Karnofsky Performance Status ≥ 70 (see Appendix 5).

7. The patient has adequate bone marrow function evidenced, at minimum, by Hgb ≥ 9 g/dL,
ANC ≥ 1.5 x 109/L and platelet count ≥ 100 x 109/L.

8. The patient has normal renal and hepatic function evidenced, at minimum, by total
serum bilirubin ≤ 2 mg/dL; AST and ALT ≤ 2.5 x ULN (upper limit of normal for the
clinical laboratory), but ≤ 5 x ULN is acceptable if due to hepatic metastases; serum
albumin ≥ 2 g/dL; and serum creatinine ≤ 2 mg/dL.

9. The patient has normal cardiac function in the opinion of the investigator and
supported by left ventricular ejection fraction (LVEF) 50% or greater on the
screening echocardiogram, no significant abnormalities on the screening ECG (eg, left
bundle branch block, III degree AV block, acute myocardial infarction or QTc interval
> 450 msec) and no history of additional risk factors for torsade de pointes (eg,
heart failure, hypokalemia or family history of Long QT Syndrome).

10. The patient has recuperated from any prior surgical procedures including at least 4
weeks rest since a major surgery.

11. The patient does not have childbearing potential or has had a negative serum
pregnancy test within the past 14 days.

12. The patient does not have reproductive potential or has agreed to use and will use an
approved method of contraception during the study and for 3 months following the last
dose of MP 470.

13. The patient is not lactating.

Exclusion Criteria:

1. The patient has a life-threatening illness, medical condition or organ system
dysfunction which, in the investigator's opinion, could compromise the patient's
safety, interfere with the absorption or metabolism of oral MP 470, or put the study
outcomes at risk.

2. The patient has any serious, uncontrolled active infection that requires systemic
treatment.

3. The patient has a history of significant cardiovascular disease such as uncontrolled
or symptomatic arrhythmias, congestive heart failure and/or myocardial infarction.

4. The patient has received any anticancer agent(s) within the past 3 weeks, including
investigational agents, chemotherapy (6 weeks for nitrosoureas or mitomycin),
immunotherapy, biologic or hormonal therapy other than LHRH agonists.

5. The patient has received radiation therapy within the past 4 weeks.

6. The patient has a grade-2 or more severe toxicity (other than alopecia) continuing
from prior anticancer therapy.

7. The patient has active CNS metastases (primary brain tumors are permitted).

8. The patient requires treatment with immunosuppressive agents other than
corticosteroids that have been at stable doses for at least 2 weeks.