Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically or cytologically confirmed adenocarcinoma of the esophagus or
gastroesophageal junction

- Metastatic disease

- Unresectable disease with no curative options

- Measurable disease with ≥ 1 lesion whose longest diameter can be accurately measured
as ≥ 2.0 cm by conventional techniques or ≥ 1.0 cm by spiral CT

- Not a candidate for a conventional multi-drug chemotherapy regimen with fairly
standard dosing (i.e., patient is able to tolerate at least 80% of standard dosing)

- Patients who have been offered and declined conventional multi-drug chemotherapy
are eligible

- No known CNS metastases

PATIENT CHARACTERISTICS:

- ECOG performance status (PS) 0-2 and age ≥ 65 years OR PS 2 and age ≥ 18 years but <
65 years

- Absolute neutrophil count ≥ 1,500/mm^3

- Platelet count ≥ 100,000/mm^3

- Total bilirubin normal

- Alkaline phosphatase ≤ 2 times upper limit of normal (ULN)

- Creatinine ≤ 1.5 times ULN

- Creatinine clearance ≥ 60mL/min

- AST and ALT ≤ 2.5 times ULN (≤ 5 times ULN in the presence of liver metastases)

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- Willing to provide tissue samples for central review and research purposes

- Able to swallow pills

- No immunocompromised patients (other than related to the use of corticosteroids),
including patients known to be HIV-positive

- No co-morbid systemic illnesses or other severe concurrent disease that, in the
judgment of the investigator, would make the patient inappropriate for this study or
interfere significantly with the proper assessment of safety and toxicity of the
prescribed regimens

- No uncontrolled intercurrent illness including, but not limited to, any of the
following:

- Ongoing or active infection

- Symptomatic congestive heart failure

- Unstable angina pectoris

- Cardiac arrhythmia

- Psychiatric illness or social situations that would limit compliance with study
requirements

- No NYHA class III or IV heart failure

- No uncontrolled hypertension except at the discretion of treating oncologist

- No other active malignancy except for nonmelanoma skin cancer or carcinoma in situ of
the cervix

- No known dihydropyrimidine dehydrogenase deficiency (DPD)

PRIOR CONCURRENT THERAPY:

- No prior chemotherapy, radiotherapy, immunotherapy, or biological therapy for
recurrent or metastatic cancer

- Prior chemotherapy or radiotherapy are allowed if they had been administered as
adjuvant or neoadjuvant therapy and a complete surgical resection of the
original cancer had been achieved

- No prior sunitinib malate

- No prior radiotherapy to > 30% of the marrow cavity at any time

- More then 4 weeks since prior major surgery

- At least 12 days since prior and no concurrent CYP3A4 inducers, including rifampin,
rifabutin, carbamazepine, phenobarbital, phenytoin, St. John's wort, efavirenz, and
tipranavir

- At least 7 days since prior and no concurrent CYP3A4 inhibitors, including azole
antifungals (ketoconazole, itraconazole), clarithromycin, erythromycin, diltiazem,
verapamil, HIV protease inhibitors (indinavir, saquinavir, ritonavir, atazanavir,
nelfinavir), and delavirdine

- No other concurrent specific treatment (other than hormonal therapy) in patients with
a history of prior malignancy