Inclusion Criteria:

- Patients must be female.

- The patient must be greater than or equal to 18 years of age and less than or equal
to 70 years of age.

- The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status
of 0 or 1.

- The tumor must be unilateral invasive adenocarcinoma of the breast on histologic
examination.

- The breast cancer must be HER2-negative based on current American Society of Clinical
Oncology (ASCO)/College of American Pathologists (CAP) Guideline Recommendations for
Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer. If the result of
the in situ hybridization testing (FISH, chromagen in situ hybridization (CISH), or
other) is equivocal, the patient is eligible if there is no plan to administer
HER2-targeted therapy.

- All of the following staging criteria (according to the 6th edition of the American
Joint Committee on Cancer (AJCC) Cancer Staging Manual) must be met: By pathologic
evaluation, primary tumor must be pT1-3; By pathologic evaluation, ipsilateral nodes
must be pN0, pN1 (pN1mi, pN1a, pN1b, pN1c), pN2a, pN3a, or pN3b. If pN0, at least one
of the following criteria must be met: ER negative and PgR negative; or Pathologic
tumor size greater than 2.0 cm; or T1c (pathologic tumor size greater than 1.0 cm but
less than or equal to 2.0 cm) and ER positive (PgR status may be positive or
negative) and either Oncotype DX® Recurrence Score of greater than or equal to 25 or
grade 3 histology.

- Patients must have undergone either a total mastectomy or breast-conserving surgery
(lumpectomy).

- For patients who undergo lumpectomy, the margins of the resected specimen must be
histologically free of invasive tumor and DCIS as determined by the local
pathologist. If pathologic examination demonstrates tumor at the line of resection,
additional operative procedures must be performed to obtain clear margins. If tumor
is still present at the resected margin after re-excision(s), the patient must
undergo total mastectomy to be eligible. (Patients with margins positive for lobular
carcinoma in situ [LCIS] are eligible without additional resection.)

- For patients who undergo mastectomy, margins must be histologically free of invasive
tumor and DCIS.

- Patients must have completed one of the following procedures for evaluation of
pathologic nodal status: Sentinel lymphadenectomy alone if pathologic nodal staging
based on sentinel lymphadenectomy is pN0, pN1mi, or pN1b; Sentinel lymphadenectomy
followed by removal of additional non-sentinel lymph nodes if the sentinel node (SN)
is positive; or Axillary lymphadenectomy without SN isolation procedure.

- The interval between the last surgery for breast cancer (treatment or staging) and
randomization must be at least 28 days but no more than 84 days.

- Patients must have ER analysis performed on the primary tumor prior to randomization.
If ER analysis is negative, then PgR analysis must also be performed. (Either a
core biopsy or surgical resection specimen can be used for ER/PgR testing.)

- The most recent postoperative blood counts must meet the following criteria: Absolute
neutrophil count (ANC) must be greater than or equal to 1200/mm3; platelet count must
be greater than or equal to 100,000/mm3; and hemoglobin must be greater than or equal
to 10 g/dL.

- The following criteria for evidence of adequate hepatic function must be met based on
the results of the most recent postoperative tests: total bilirubin must be less than
or equal to upper limits of normal (ULN)for the lab unless the patient has a
bilirubin elevation less than ULN to 1.5 x ULN due to Gilbert's disease or similar
syndrome involving slow conjugation of bilirubin; and alkaline phosphatase must be
less than or equal to 2.5 x ULN for the lab; and AST must be less than or equal to
1.5 x ULN for the lab. Alkaline phosphatase and aspartate transaminase (AST) may not
both be greater than the ULN. For example, if the alkaline phosphatase is greater
than the ULN but less than or equal to 2.5 x ULN, then the AST must be less than or
equal to the ULN. If the AST is greater than the ULN but less than or equal to 1.5 x
ULN, then the alkaline phosphatase must be less than or equal to ULN.

- Patients with AST or alkaline phosphatase greater than ULN are eligible for inclusion
in the study if liver imaging (CT, MRI, PET-CT, or PET scan) does not demonstrate
metastatic disease and the requirements for adequate hepatic function are met.

- Patients with alkaline phosphatase that is greater than ULN but less than or equal to
2.5 x ULN are eligible for inclusion in the study if a bone scan, PET-CT, or PET scan
does not demonstrate metastatic disease.

- The most recent postoperative serum creatinine must be less than or equal to ULN for
the lab.

- A urine sample must be tested for proteinuria by the dipstick method. Eligibility
must be based on the most recent postoperative test result(s) performed within 6
weeks prior to randomization. Urine dipstick must indicate 0-1+ protein. If
dipstick reading is greater than or equal to 2+, a 24-hour urine specimen must be
collected and must demonstrate less than 1 gram of protein.

- Left ventricular ejection fraction (LVEF) assessment by 2-D echocardiogram or
multigated acquisition (MUGA) scan must be performed within 90 days prior to
randomization. The LVEF must be greater than or equal to 50% regardless of the
facility's lower limits of normal (LLN).

Exclusion Criteria:

- T4 tumors including inflammatory breast cancer.

- Definitive clinical or radiologic evidence of metastatic disease.

- Synchronous or metachronous contralateral invasive breast cancer. (Patients with
synchronous and/or metachronous contralateral DCIS are eligible.)

- Any history of ipsilateral invasive breast cancer or ipsilateral DCIS.

- History of non-breast malignancies within 5 years prior to randomization, except for
the following: carcinoma in situ of the cervix, colorectal carcinoma in situ,
melanoma in situ, and basal cell and squamous cell carcinomas of the skin.

- Previous therapy with anthracyclines, taxanes, or bevacizumab for any malignancy.

- Chemotherapy administered for the currently diagnosed breast cancer prior to
randomization.

- Continued therapy with any hormonal agent such as raloxifene or tamoxifen (or other
SERM) or an aromatase inhibitor. (Patients are eligible if these medications are
discontinued prior to randomization.)

- Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement
therapy. Patients are eligible if these medications are discontinued prior to
randomization.

- Active hepatitis B or hepatitis C with abnormal liver function tests.

- Cardiac disease (history of and/or active disease) that would preclude the use of the
drugs included in the treatment regimens. This includes but is not confined to 1)
Active cardiac disease: angina pectoris that requires the use of anti-anginal
medication; ventricular arrhythmias except for benign premature ventricular
contractions; supraventricular and nodal arrhythmias requiring a pacemaker or not
controlled with medication; conduction abnormality requiring a pacemaker; valvular
disease with documented compromise in cardiac function; and symptomatic pericarditis,
2) History of cardiac disease: myocardial infarction documented by elevated cardiac
enzymes or persistent regional wall abnormalities on assessment of left ventricular
(LV) function; history of documented congestive heart failure (CHF); and documented
cardiomyopathy.

- Uncontrolled hypertension defined as systolic BP greater than 150 mmHg or diastolic
BP greater than 90 mmHg, with or without anti-hypertensive medication. Patients with
initial BP elevations are eligible if initiation or adjustment of BP medication
lowers pressure to meet entry criteria.

- History of hypertensive crisis or hypertensive encephalopathy.

- History of transient ischemic attack (TIA) or cerebrovascular accident (CVA).

- History of any arterial thrombotic event within 12 months prior to randomization.

- Symptomatic peripheral vascular disease.

- Intrinsic lung disease resulting in dyspnea.

- Unstable diabetes mellitus.

- Active infection or chronic infection requiring suppressive antibiotics.

- History of a major organ allograft or condition requiring chronic immunosuppression,
e.g., kidney, liver, lung, heart, bone marrow transplant, or autoimmune diseases.
(Patients who have received corneal transplants, cadaver skin, or bone transplants
are eligible.)

- Any significant bleeding within 180 days prior to randomization, exclusive of
menorrhagia in premenopausal women.

- Non-healing wound, skin ulcers, or incompletely healed bone fracture.

- Major surgical procedure, open biopsy, or significant traumatic injury within 28 days
prior to the planned start of study therapy.

- Anticipation of need for major surgical procedures during study therapy and for at
least 3 months following completion of bevacizumab.

- Gastroduodenal ulcer(s) documented by endoscopy to be active within 6 months before
randomization.

- History of GI perforation, abdominal fistulae, or intra-abdominal abscess.

- Known bleeding diathesis or coagulopathy.

- Requirement for therapeutic doses of coumadin or equivalent.

- Sensory/motor neuropathy greater than or equal to grade 2, as defined by the NCI
Common Terminology Criteria for Adverse Events (CTCAE) v3.0.

- Conditions that would prohibit administration of corticosteroids.

- Chronic daily treatment with corticosteroids (dose of greater than or equal to 10
mg/day methylprednisolone equivalent) (excluding inhaled steroids).

- History of hypersensitivity reaction to drugs formulated with polysorbate 80.

- Pregnancy or lactation at the time of study entry.

- Other non-malignant systemic disease that would preclude the patient from receiving
study treatment or would prevent required follow-up.

- Psychiatric or addictive disorders or other conditions that, in the opinion of the
investigator, would preclude the patient from meeting the study requirements.

- Use of any investigational product within 4 weeks prior to randomization.