Trial Information

Identification and Treatment of Depression in Underserved African American and Latino Patients With Cancer

Study Groups:

If you agree to take part in this study, you will be randomly assigned (as in the flip of a
coin) to 1 of 2 groups: telephone intervention or standard care. You have an equal chance
of being assigned to either group.

No matter which group you are assigned to, you will be asked to tell your doctor and/or
nurse about all symptoms you may be experiencing during your regularly scheduled visits.
You will also be asked to call your doctor and/or nurse right away when your symptoms are
severe. The doctor and/or nurse will give you instructions about calling when your symptoms
are severe.

You will receive educational material about emotional distress, sadness, and depression in
people who are being treated for cancer. The material also will tell you about community
resources that are available for people with cancer.

Feedback Group:

If you are assigned to the feedback group, your symptom information will be collected using
a telephone system. You will be asked to rate 13 symptoms, such as sadness, emotional
distress, and fatigue, on a scale of 0 to 10 using the touch tone key pad of your telephone.
The 0 means that you are not having the symptom at all, and the 10 means that the symptom
is as bad as you can imagine.

If you rate either of the 2 symptoms of sadness and/or emotional distress as moderate or
severe, then the telephone system will send a message to the research staff and your doctor
or nurse right away. Only the symptoms of sadness and emotional distress will be reported
right away to the doctor or nurse and the research staff. If you answer moderate to severe
to any other questions, it will not be sent right away to the doctor, nurse or study staff.
The telephone system usually works very well. But, if for any reason the telephone system
is not working, the research staff will report any moderate or severe sadness or distress to
your doctor or nurse. Your doctor or nurse also will receive a written summary of your
symptom ratings before your next clinic visit.

Standard Care Group:

If you are assigned to the standard care group, your symptom information will not be
collected using the telephone system. You will be asked to tell your doctor and/or nurse
about all symptoms you may be experiencing.

Telephone System:

For patients in the feedback group, the research staff will teach you how to use a telephone
system for measuring your symptoms. The research staff also will ask you to practice using
the telephone system. The telephone system will call you 1 time a week for 16 weeks. You
will be asked to rate your symptoms and how much the symptoms interfere with your life. You
can set up a time to receive the phone calls that works best for you. Rating your symptoms
using the telephone system will take about 5 minutes for each call.

If you do not answer the telephone system on the first call, then the system will try to
reach you 3 more times. If you do not answer after the fourth try, then the research staff
will call you to find out why you could not answer the telephone system. If you prefer, the
research staff will change the day or time that the telephone system calls you.

Questionnaires and Interviews:

You will be asked to fill out 3 questionnaires during 3 regularly scheduled clinic visits.
These questionnaires ask questions about pain, stress, sadness, quality of life, and other
symptoms you may be experiencing. You will also compete an interview at the first and third
visit. During the interview, you will be asked questions about your feelings and emotions.
The questionnaires and interview will be completed at the following times:

- At the first visit when you enroll in the study, 8-10 weeks after the study begins, and
14-16 weeks after the study begins, you will complete the questionnaires. This will
take about 45 minutes.

- At the first visit and 14-16 weeks after the study begins, you will complete a short
interview. Completing the interview will take about 15 minutes.

Length of Study:

Your participation in this study will last up to 16 weeks.

This is an investigational study.

Up to 166 patients will take part in this study. All will be enrolled at MD Anderson.