Dexmedetomidine and Hypoxic Pulmonary Vasoconstriction in Thoracic Surgical Procedure and One-Lung Ventilation(OLV)
To collect data on the effects of Dexmedetomidine(DEX)(0.3mcg/kg loading dose followed by an
infusion of 0.3mcg/kg/hr)on Hypoxic pulmonary vasoconstriction when administered to patients
during surgery with one lung ventilated thoracic procedures. Dexmedetomidine has both
vasoconstricting and vasodilatatory effect on peripheral vasculature but its effect on
pulmonary vessels is not known. If it is predominantly a vasodilator on pulmonary vessels it
can inhibit hypoxic pulmonary vasoconstriction and will increase shunting of venous blood to
arterial circulation without oxygenation. If our study proves it to be a vasodilator for
pulmonary vessels then it will not be wise to use it in thoracic procedure with one lung
ventilation. If our study proves that it is a vasoconstrictor for pulmonary vessels, then it
will be an excellent adjunct to other anesthetic agents during one lung ventilation.
Observational
Observational Model: Case-Only, Time Perspective: Cross-Sectional
The primary outcome will be changes in oxygenation measured by the PaO2 during one lung ventilation
During thoracic surgical procedure
Yes
joseph tobias, md
Principal Investigator
University of Missouri-Columbia
United States: Institutional Review Board
1124100 Hospira
NCT00839605
March 2009
November 2009
Name | Location |
---|---|
University Of Missouri-Columbia | Columbia, Missouri 65212 |