Inclusion Criteria:

- Histologically documented lymphoid malignancies, regardless of their origin (B,T or
NK). These include ALL, CLL, HL, NHL, MM and PCL.

- Patients must have failed at least one standard regimen of chemotherapy for their
illness. They may have had unlimited prior regimens.

- Performance status of ≤ 2 as per ECOG scale.

- ALT < 2.5 times the upper limit of normal

- Anticipated life expectancy of at least 12 weeks

- Patients will be allowed to have baseline cytopenias, but ANC should be >200/μl and a
platelet count > 25,000/ μl (within 2 weeks of starting therapy).

- Patients must have a serum creatinine level ≤ 2 mg/dL (within 2 weeks of starting
therapy).

- Male or female adults of at least 18 years of age.

- Signed written informed consent and willingness to meet follow-up schedule and study
procedure obligations

- Left Ventricular Ejection Fraction (LVEF) > 40% by echocardiogram or MUGA scan
performed within 60 days prior to registration

- Women and men of childbearing potential must agree to employ adequate contraception
to prevent pregnancy while on therapy.

Exclusion Criteria:

- Chemotherapy or radiotherapy received within the previous 2 weeks.

- Uncontrolled, active infection requiring IV antibiotics.

- Psychiatric illness that could potentially interfere with the completion of treatment
according to this protocol.

- Pregnant or potential for pregnancy.

- Breast-feeding.

- Prior asparaginase therapy complicated by pancreatitis, allergic reaction,
hemorrhagic event, or thrombosis

- Previous treatment with pegylated asparaginase

- Prior doxorubicin exposure, more than 400 mg/m2

- Clinically significant CHF

- No prior malignancy is allowed except for adequately treated basal cell or squamous
cell skin cancer, in situ cervical cancer, or other cancer for which the patient has
been disease free for at least three years. Prior malignancy is acceptable provided
there has been no evidence of disease within the three year interval.