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Low-Fat Diet and Omega-Fatty Acids for Prostate Cancer Prevention


N/A
40 Years
75 Years
Open (Enrolling)
Male
Prostate Cancer

Thank you

Trial Information

Low-Fat Diet and Omega-Fatty Acids for Prostate Cancer Prevention


Experiments have shown that a low fat diet high in fish oil may prevent the progression of
prostate cancer. The purpose of this study is to determine if a low-fat diet combined with
fish oil capsules will change the chemical substances present in blood and prostate tissue
that are related to the growth of cancer cells. This study will compare how these substances
are affected by either, a typical high-fat Western diet, or a low-fat diet combined with
fish oil.


Inclusion Criteria:



- Has been diagnosed with adenocarcinoma (cancer)

- Able to sign the consents to participate.

- Is medically able to receive and comply with the dietary intervention.

- Accessible geographically and by telephone for nutritional counseling and follow up.

- Has elected to undergo radical prostatectomy.

- Agrees to stop taking dietary or vitamin supplements (Lycopene, Vitamin E, selenium,
genistein) or herbal supplements (eg. saw palmetto, PC-SPES) for 1 week prior to
starting the study.

- Can safely stop taking aspirin, COX-2 inhibitors, and other anti-inflammatory
medications for 1 week prior to starting the study.

- Can safely stop taking fish oil capsules 2-weeks prior to starting the diet
intervention.

Exclusion Criteria:

- Is taking LHRH agonists, androgen receptor blocking agents or finasteride.

- Has undergone bilateral orchiectomy.

- Has a bleeding disorder.

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

fat acid ratio

Outcome Time Frame:

3 months

Safety Issue:

No

Principal Investigator

William Aronson, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of California, Los Angeles

Authority:

United States: Institutional Review Board

Study ID:

01-07-026-21

NCT ID:

NCT00836615

Start Date:

January 2006

Completion Date:

December 2011

Related Keywords:

  • Prostate Cancer
  • Low-fat diet
  • Western diet
  • fish oil capsules
  • prostate cancer
  • UCLA
  • radical prostatectomy
  • Prostatic Neoplasms

Name

Location
University of California, Los Angeles Los Angeles, California