Inclusion Criteria:

- Have unilateral lymphedema of the ipsilateral arm attributed to prior surgical
treatment or radiation therapy for cancer that is severe enough to warrant therapy in
the opinion of the patient and treating physician.

- All patients must have greater than a 3 cm total difference in arm circumference
between the affected and unaffected arm measured at five defined points (see
protocol).

- Be at least 18 years of age

- Have adequate organ function as specified in the protocol.

- Agree to use effective contraceptive methods during the course of the study if the
patient has child-producing potential

- Have an ECOG performance status of 0 or 1

Exclusion Criteria:

- Pregnant, lactating, or unwilling to use appropriate birth control

- Active infection

- Patients may not have clinically significant cardiovascular disease including
myocardial infarction within 6 months prior to initiation of therapy, unstable
angina, New York Heart Association (NYHA) grade II or greater congestive heart
failure, grade II or greater peripheral vascular disease, uncontrolled hypertension
defined as SBP>160 or DBP>90. Patients may not have any prior history of
cerebrovascular disease including TIA or stroke.

- Locally recurrent or metastatic disease

- Concurrent therapeutic anticoagulation or any history of DVT or PE.

- Major surgery within 4 weeks of starting protocol therapy (non-operative biopsy or
placement of a vascular access device is not considered major surgery)

- Radiation therapy or chemotherapy within the past 6 weeks or currently undergoing
radiation therapy or chemotherapy (Concurrent adjuvant hormonal therapy is allowed.)

- Altered the physical therapy regimen within the past month

- Indwelling venous device in the ipsilateral arm

- Bilateral lymphedema

- Concomitant requirement for medication classified as substrates for the CYP450
enzymes and listed as prohibited in the protocol.