A Randomized, Multicenter, Phase 2 Study to Compare the Efficacy of Panitumumab in Combination With mFOLFOX6 to the Efficacy of Bevacizumab in Combination With mFOLFOX6 in Patients With Previously Untreated, KRAS Wild-Type, Unresectable, Metastatic Colorectal Cancer

Inclusion Criteria:

- Histologically or cytologically-confirmed adenocarcinoma of the colon or rectum in
subjects with unresectable metastatic (M1) disease

- Subjects with at least 1 uni-dimensionally measurable lesion of at least 10mm per
modified RECIST guidelines

- Wild-type KRAS tumor status confirmed by an Amgen approved central laboratory or an
experienced laboratory (local laboratory) per local regulatory guidelines using a
validated test method

- Eastern Cooperative Oncology Group (ECOG) score of 0 or 1

- Men or women 18 years of age or older

- Adequate hematologic, renal, hepatic, metabolic, and coagulation function

Exclusion Criteria:

- History of prior or concurrent central nervous system (CNS) metastases

- Prior chemotherapy or other systemic anticancer therapy for treatment of metastatic
colorectal carcinoma

- Clinically significant cardiac disease

- Clinically significant peripheral sensory neuropathy

- Active inflammatory bowel disease

- Recent gastroduodenal ulcer to be active or uncontrolled

- History of interstitial lung disease

- Recent pulmonary embolism, deep vein thrombosis, or other significant venous event

- Pre-existing bleeding diathesis and/or coagulopathy with exception of well-controlled
anticoagulation therapy

- Recent major surgical procedure, open biopsy, or significant traumatic injury not yet
recovered from prior major surgery