Inclusion Criteria:

- invasive breast cancer

- stage I-IIIA disease

- ER, PR, Her2/neu-negative status

- no prior treatment for breast cancer

- age 18 years of greater

- normal renal, liver function

- normal hematologic status

- ECOG Performance status 0, 1

- Evaluation by a surgeon to determine breast conservation eligibility

- Women of childbearing potential must have a documented negative pregnancy test within
2 months of study trial entry and agree to birth control during the duration of the
trial therapy

- Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

- Metastatic breast cancer

- Inoperable breast cancer, including Stage IIIB and IIIC

- Tumor size less than 1 centimeter

- Prior surgery, systemic therapy, or radiotherapy for the current cancer

- Hormone receptor-positive breast cancer

- Her2/neu-positive breast cancer

- Any concurrent condition which in the investigator's opinion makes it inappropriate
for the patient to participate in the trial or which would jeopardize compliance with
the protocol

- Pregnant or nursing women

- Receipt of any investigational agents within 30 days prior to commencing study
treatment